The rejuvenating effect of pregnancy on muscle regeneration

Aging Cell
Tal Falick MichaeliYuval Gielchinsky

Abstract

Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show a markedly impaired propensity to proliferate in response to damage. However, exposure to factors present in the serum of young mice restores the regenerative capacity of aged precursor cells. As pregnancy represents a unique biological model of a partially shared blood system between young and old organisms, we hypothesized that pregnancy in aged mice would have a rejuvenating effect on the mother. To test this hypothesis, we assessed muscle regeneration in response to injury in young and aged pregnant and nonpregnant mice. Muscle regeneration in the aged pregnant mice was improved relative to that in age-matched nonpregnant mice. The beneficial effect of pregnancy was transient, lasting up to 2 months after delivery, and appeared to be attributable to activation of satellite cells via the Notch signaling pathway, thus supporting the possibility that pregnancy induces activation of aged dormant muscle progenitor cells.

References

Dec 4, 2003·Science·Irina M ConboyThomas A Rando
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher GreggSamuel Weiss

❮ Previous
Next ❯

Citations

Mar 6, 2017·Biochemistry. Biokhimii︠a︡·V A PopkovD B Zorov
Jun 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rodney M RitzelLouise D McCullough
Apr 11, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krishna M SinhaJohnny Huard
Sep 2, 2015·Journal of Neuromuscular Diseases·Matthew ThorleyStéphanie Duguez
Sep 30, 2018·Scientific Reports·Vasily A PopkovDmitry B Zorov
Jan 4, 2019·Nature Cell Biology·Salah MahmoudiAnne Brunet
Oct 2, 2019·Frontiers in Physiology·Marie Elena BeyKirsten Legerlotz
Dec 7, 2016·Frontiers in Cell and Developmental Biology·Clara Di GermanioBarbara Barboni
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aiping LuJohnny Huard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Fertility and Sterility
Tal Falick MichaeliYuval Gielchinsky
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Arnold Koller, Christian Haid
© 2021 Meta ULC. All rights reserved