PMID: 3768287Sep 1, 1986Paper

The relation between aldosterone concentrations in plasma and saliva during pregnancy

British Journal of Obstetrics and Gynaecology
J D FewV H James

Abstract

The concentrations of aldosterone and glucocorticoids (cortisol + cortisone) were measured in saliva and plasma samples obtained from healthy women during early (11-19 weeks), mid (24-29 weeks) and late (32-37 weeks) pregnancy. There was a progressive increase in mean aldosterone levels in both saliva and plasma throughout pregnancy, though at each stage of pregnancy the range was very wide. Glucocorticoid levels increased up to mid-pregnancy and then remained constant. At no stage were aldosterone and glucocorticoid levels significantly correlated. The proportion of free (non-protein bound) aldosterone in plasma, and the saliva:plasma ratio of aldosterone did not differ from the non-pregnant range at any stage of pregnancy. We conclude that measurement of aldosterone concentration in saliva is a convenient and valid method for the estimation of plasma free aldosterone in pregnancy and so provide a non-invasive technique for assessing aldosterone status throughout pregnancy.

References

Jun 1, 1979·Pediatric Research·R McVieM I New
Jan 1, 1975·The Journal of Clinical Endocrinology and Metabolism·R J WierM Tree
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·T C SmeatonI S Fulton
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Jun 1, 1984·Journal of Steroid Biochemistry·B Bustamante, J Crabbé
Jul 1, 1984·Journal of Steroid Biochemistry·J D FewV H James
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Mar 1, 1959·Acta Endocrinologica·K M JONESF C GREENWOOD

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Citations

Feb 1, 1987·Journal of Steroid Biochemistry·J D FewV H James
Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J S KoonerV H James
Mar 14, 2014·Frontiers in Endocrinology·Kristin M Voegtline, Douglas A Granger
Jan 1, 1989·British Journal of Obstetrics and Gynaecology·K J StevensJ D Few
Apr 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·G MastertonB Roxburgh
Jul 8, 2016·Annals of Clinical and Translational Neurology·Yasuhiro HijikataGen Sobue
Jan 30, 2009·Annals of Clinical Biochemistry·Peter Wood

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