Abstract
The apolipoprotein E gene (APOE) is associated with coronary heart disease and stroke, but the relation with peripheral artery disease (PAD) is unknown. We investigated the relation of APOE genotype with PAD and other types of vascular disease. The cross-sectional association between APOE genotype and ankle-brachial index (ABI) and vascular disease prevalence; and the prospective relation with incident PAD and other types of vascular disease (coronary artery disease, stroke and vascular mortality) were evaluated in 7418 patients from the Secondary Manifestations of ARTerial disease (SMART) study. This is a prospective cohort study in patients with cardiovascular disease or a cardiovascular risk factor. Analyses were adjusted for age and sex. Mean age was 56.7 ± 12.4 years and 68% of the patients was male. APOE genotype frequencies were ε2ε2 1.3%; ε2ε3 9.9%; ε2ε4 2.4%; ε3ε3 56.9%; ε3ε4 26.7% and ε4ε4 2.8%. Median follow-up time was 8.1 years (IQR 5.4-11.4) in which 452 new PAD events occurred. The ε2ε2 genotype was significantly associated with a lower ABI (regression coefficient -0.04, 95%CI -0.07 to -0.01), increased PAD prevalence (prevalence ratio 1.54, 95%CI 1.01-2.17) and a higher risk of incident PAD (HR 2.31, 95%CI 1.29-...Continue Reading
References
Jun 22, 2000·Genetic Epidemiology·H E ResnickT B Harris
Aug 3, 2001·Archives of Internal Medicine·Y CuiT L Bush
Sep 15, 2005·Circulation·Scott M GrundyUNKNOWN National Heart, Lung, and Blood Institute
Aug 16, 2006·Circulation·Beatrice A GolombMichael H Criqui
Sep 19, 2006·Journal of Clinical Epidemiology·A Rogier T DondersKarel G M Moons
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Anna M BennetJohn Danesh
Jan 26, 2011·Journal of Clinical Lipidology·Karine TremblayDaniel Gaudet
Feb 6, 2013·European Heart Journal·Tanja B GrammerWinfried März
Apr 10, 2013·International Journal of Epidemiology·Tauseef A KhanJuan P Casas
Jul 3, 2013·Journal of Hypertension·Giuseppe ManciaUNKNOWN Task Force Members
Sep 26, 2013·Nature Reviews. Cardiology·Gerald F WattsDick C Chan
Jan 11, 2014·Critical Reviews in Clinical Laboratory Sciences·A D MaraisD J Blom
Jun 21, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C KoopalF L J Visseren
Feb 28, 2015·Journal of Vascular Surgery·Michael S Conte, Frank B Pomposelli
Mar 15, 2015·Atherosclerosis·C KoopalF L J Visseren
Citations
Jun 23, 2016·Neuroscience Letters·Satrupa DasAnjana Munshi
Oct 21, 2016·Environmental Research·Diddier PradaAndrea A Baccarelli
Jan 19, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Charlotte KoopalFrank L J Visseren
Mar 2, 2017·PloS One·Sandra MastroiannoAldo Russo
Mar 27, 2020·Disease Markers·Yujing HuYan Wang
Mar 22, 2020·Diabetes·Alan ChaitKarin E Bornfeldt
Jan 22, 2020·Journal of Clinical Lipidology·Martine PaquetteAlexis Baass
Feb 5, 2021·Frontiers in Cardiovascular Medicine·Alena S LimonovaOxana M Drapkina
Aug 21, 2020·EBioMedicine·Amanda L LumsdenElina Hyppönen
Jul 20, 2021·International Heart Journal·Tatsuya FukaseTohru Minamino
Jun 5, 2019·Cardiology·Yan LongJi-Xuan Liu