The Relation Between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 1: Theoretical Models

Frontiers in Physiology
Adrien LückerPatrick Jenny

Abstract

Capillary dysfunction impairs oxygen supply to parenchymal cells and often occurs in Alzheimer's disease, diabetes and aging. Disturbed capillary flow patterns have been shown to limit the efficacy of oxygen extraction and can be quantified using capillary transit time heterogeneity (CTH). However, the transit time of red blood cells (RBCs) through the microvasculature is not a direct measure of their capacity for oxygen delivery. Here we examine the relation between CTH and capillary outflow saturation heterogeneity (COSH), which is the heterogeneity of blood oxygen content at the venous end of capillaries. Models for the evolution of hemoglobin saturation heterogeneity (HSH) in capillary networks were developed and validated using a computational model with moving RBCs. Two representative situations were selected: a Krogh cylinder geometry with heterogeneous hemoglobin saturation (HS) at the inflow, and a parallel array of four capillaries. The heterogeneity of HS after converging capillary bifurcations was found to exponentially decrease with a time scale of 0.15-0.21 s due to diffusive interaction between RBCs. Similarly, the HS difference between parallel capillaries also drops exponentially with a time scale of 0.12-0.19 ...Continue Reading

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Citations

Aug 31, 2019·PLoS Computational Biology·Franca SchmidPatrick Jenny
Dec 14, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Laura A MaitozaRichard W Pierce
Sep 26, 2019·Frontiers in Computational Neuroscience·Liwei GuoYiannis Ventikos
Nov 26, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Tuhin K Roy, Timothy W Secomb
Aug 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yujia Qi, Marcus Roper

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Methods Mentioned

BETA
phosphorescence

Software Mentioned

OpenFOAM
SciPy

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