PMID: 7027713Nov 1, 1981Paper

The relation between catecholamines, glucagon and pancreatic polypeptide during hypoglycaemia in man

Acta Endocrinologica
J JärhultT W Schwartz

Abstract

The effects of insulin hypoglycaemia (0.15 IU/kg) on plasma adrenaline, noradrenaline, dopamine, glucagon and pancreatic polypeptide (PP) concentrations were investigated in 6 adrenalectomized subjects and 6 healthy controls. Both the rise in mean plasma insulin and the fall in mean blood glucose concentration were closely similar in the two groups. Mean plasma adrenaline concentration rose by about 3 nmol/l in the normal subjects, but remained unchanged in adrenalectomized subjects. Mean plasma noradrenaline concentration increased by about 2 nmol/l in both groups. Despite the large difference in adrenaline concentrations during hypoglycaemia, there was no significant difference between the responses of the endocrine pancreas of the normal and adrenalectomized subjects. Thus, mean plasma glucagon concentration rose by about 30 pmol/l and mean plasma PP concentration by about 150 pmol/l in each group. We conclude that the release of glucagon and PP during hypoglycaemia does not depend upon changes in plasma adrenaline concentration in man.

Citations

Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H MönnikesR Arnold
Nov 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C F TosoL M Linares
Oct 1, 1983·Journal of the Autonomic Nervous System·T W Schwartz
Jun 5, 1982·Lancet·N J Christensen
Jun 5, 1982·Lancet·H KolbJ van der Bosch
Apr 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·D LiuN Clausen-Sjöbom
Apr 1, 1983·The American Journal of Physiology·G RibesM M Loubatieres-Mariani
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Jul 1, 1984·The American Journal of Physiology·N J ChristensenS Madsbad
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