The relation between depth of trophoblastic invasion and beta-HCG levels in tubal pregnancies

Archives of Gynecology and Obstetrics
M KleinP Husslein

Abstract

beta-HCG (human chorionic gonadotropin) values of over 2500 I.U./l are associated with higher failure rates for therapy with prostaglandin F2 alpha in tubal pregnancies. The purpose of our study was to ascertain if the 2500 I.U./l limit correlates with histopathology. We therefore compared the pre-operative beta-HCG-values and intraluminal and extraluminal trophoblast growth in tubal pregnancy. Purely intraluminal trophoblast was significantly more frequent in patients of group I (beta-HCG < 2500 I.U./l), while group II patients (beta-HCG > 2500 I.U./l) almost exclusively had extraluminal growth (P = 0.0045). Since the efficacy of prostaglandin F2 alpha therapy depends on intact tubal musculature the correlation of the beta-HCG threshold level with histopathologic findings may explain the high failure rate in patients with beta-HCG values above 2500 I.U./l.

References

Oct 1, 1987·Fertility and Sterility·P S CartwrightJ R Anderson
Jun 1, 1989·British Journal of Obstetrics and Gynaecology·H ZakutD Bernstein
Sep 1, 1989·Geburtshilfe und Frauenheilkunde·C EgarterH Kiss
May 14, 1988·Lancet·C Egarter, P Husslein

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Citations

Oct 21, 2005·Reproductive Biology and Endocrinology : RB&E·Elsebeth Staun-Ram, Eliezer Shalev
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·P Bischof, A Campana
Nov 5, 2011·Molecular and Cellular Endocrinology·Jessie Z-J ChenRosemary J Keogh
Mar 24, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P P PereiraM Zugaib
Oct 16, 2007·Gynecologic and Obstetric Investigation·Marie Cohen, Paul Bischof
Feb 25, 2015·International Journal of Surgical Pathology·Onur ErolCem Sezer

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