PMID: 2441021Jun 1, 1987

The relation between effects of adenosine, theophylline and enprofylline on the contractility of sensitized guinea-pig lung strips

The Journal of Pharmacy and Pharmacology
F E Napier, D M Temple


Contractile responses of lung parenchymal strips from ovalbumin-sensitized guinea-pigs to cumulative addition of antigen were significantly potentiated by 10 min pretreatment with adenosine 10 microM. This potentiation was unaffected by the adenosine uptake inhibitor, dipyridamole, 2 microM. Cumulative addition of adenosine 0.1-100 microM to parenchymal strips without antigen produced variable responses, unrelated to sensitization, some contracting, some relaxing. Theophylline 100 microM caused relaxation of parenchymal strips and significantly inhibited the antigen-induced contraction with a parallel shift of the log concentration-response line. It also inhibited the adenosine-induced potentiation of contraction. Enprofylline 100 microM caused a greater relaxation of the tissue than theophylline. While it inhibited the adenosine-induced potentiation of the response, enprofylline, in contrast to theophylline, failed to inhibit the antigen-induced contraction of guinea-pig parenchyma. At these concentrations, theophylline and enprofylline each inhibited the antigen-induced release of SRSA (leukotrienes C4, D4 and E4), and of histamine, from sensitized guinea-pig lung fragments.


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