The relation between multiple sleep latency test findings and the frequency of apneic events in REM and non-REM sleep

Chest
R D Chervin, M S Aldrich

Abstract

A recent study of 34 patients with mild obstructive sleep apnea syndrome (OSAS) suggested that the number of apneas and hypopneas per hour of sleep (apnea/hypopnea index [AHI]) may show a stronger correlation with sleepiness, as measured by the Multiple Sleep Latency Test (MSLT), when calculated for rapid eye movement (REM) sleep alone (AHIR) as opposed to the entire night. We sought to reexamine this possibility in a larger group of similar patients and in patients who had a wider range of OSAS severity. Retrospective and observational. A large, accredited, academic sleep disorders center where a database of sleep study results is maintained. We studied 1,146 persons who had polysomnography and MSLTs for clinical indications. In linear regression models, the AHI explained 11.0% of the variance in MSLT results, AHIN (AHI during non-REM sleep) explained 10.8%, and AHIR explained only 6.0% (p < or = 0.0001 for each). Among subjects with AHI < 10, the AHI explained 3.1% of the variance (p=0.0012), the AHIN 2.3% (p=0.0049), and the AHIR 0.2% (p=0.40). Among all subjects, the ratio AHIR/AHIN had no influence on the overall relationship between AHI and sleepiness (p=0.23). We conclude that apneic events during REM and non-REM sleep p...Continue Reading

References

Mar 1, 1992·Archives of Internal Medicine·K CheshireN J Douglas
Jul 1, 1991·Neurology·M S Aldrich, B Jahnke
Jun 1, 1990·Archives of Internal Medicine·M S Aldrich, J B Chauncey
Jul 1, 1988·Chest·C GuilleminaultG Nino-Murcia
May 1, 1974·Psychophysiology·W B Webb, H W Agnew
May 1, 1981·Electroencephalography and Clinical Neurophysiology·A A BorbélyD Lehmann
Feb 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M I AsherJ Milic-Emili
Dec 1, 1995·Nature Medicine·R D Chervin, C Guilleminault
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·R D ChervinC Guilleminault
Feb 1, 1994·Chest·N J MoserL Harbison
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·M S Aldrich, J E Shipley
Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·J E KassM R Pratter

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Citations

Jul 11, 2003·Respiratory Physiology & Neurobiology·Jed Black
Sep 14, 2007·Journal of Clinical and Experimental Neuropsychology·Agnès DauratMichel Tiberge
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·R D Chervin, M S Aldrich
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·R D Chervin
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Hassan A ChamiDaniel J Gottlieb
Jun 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Chen-San SuNancy Foldvary-Schaefer
Jun 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Babak Mokhlesi
Mar 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Akram KhanUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Jun 27, 2014·PloS One·Philipp O ValkoChristian R Baumann
Oct 9, 2014·American Journal of Respiratory and Critical Care Medicine·Babak MokhlesiPaul E Peppard
Mar 13, 2016·Sleep & Breathing = Schlaf & Atmung·Sang-Ahm LeeSu-Hyun Han
Dec 27, 2005·Sleep Medicine Reviews·Jianhua ShenColin M Shapiro
Feb 15, 2008·Diabetes Care·Giora Pillar, Naim Shehadeh
Sep 2, 2016·Current Opinion in Pulmonary Medicine·Mohammed Alzoubaidi, Babak Mokhlesi
Jul 21, 2009·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Denis MartinezMaria do Carmo Sfreddo Lenz
Mar 13, 2012·Cephalalgia : an International Journal of Headache·M BarloeseR Jensen
Jul 10, 2014·Cephalalgia : an International Journal of Headache·M BarloeseR Jensen
Oct 14, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Trond Sand, Harald Schrader
Jan 30, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Ina DjonlagicRobert Stickgold
Jun 18, 2017·Sleep & Breathing = Schlaf & Atmung·Vincent Mysliwiec, Matthew S Brock
Sep 21, 2018·Sleep & Breathing = Schlaf & Atmung·Andrew W Varga, Babak Mokhlesi
Oct 21, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I M MadaevaL I Kolesnikova
Jul 6, 2000·Neurology·R D ChervinK M Hedger

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