The relation between ponderosity and coronary risk factors in children and their relatives. The Muscatine Ponderosity Family Study

American Journal of Epidemiology
T L BurnsR M Lauer

Abstract

A family study was conducted in Muscatine, Iowa in 1984-1985 to evaluate the relation between ponderosity in children and coronary risk factor levels in these children and in their family members, and the genetic contribution to familial clustering of levels of ponderosity (body weight relative to height). Four groups of probands were selected from the 1,783 students who participated in three consecutive biennial school surveys. A random group (n = 70), a random sample of students from the entire pool; a lean group (n = 72), students in the lowest quintile of relative weight on all three surveys; a gain group (n = 70), students who gained at least two quintiles of relative weight over the four-year period; and a heavy group (n = 72), students in the highest quintile of relative weight on all three surveys. The parents, siblings, a related aunt or uncle, and a first cousin of these probands were also examined. The data show that levels of high density lipoprotein (HDL) cholesterol, apolipoproteins A-1 and B, and systolic blood pressure in heavy group probands are consistent with increased coronary risk. This same association exists among the relatives with excess ponderosity. Levels of body mass index in the mothers, fathers, an...Continue Reading

Associated Clinical Trials

Citations

Jun 1, 1992·Journal of the American College of Nutrition·K F ZwiauerK Widhalm
Sep 11, 2013·Circulation·Aaron S KellyUNKNOWN American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascula
Feb 4, 1998·Hypertension·S R DanielsB A Barton
Jan 1, 1993·Critical Reviews in Food Science and Nutrition·T L BurnsR M Lauer
Oct 1, 1996·Journal of Epidemiology and Community Health·R J RonaS Chinn
Aug 14, 1998·Journal of Pediatric Gastroenterology and Nutrition·L A MorenoM Bueno
Nov 6, 1995·American Journal of Medical Genetics·R CarmiV C Sheffield
Jan 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Q HeJ Karlberg
Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P T WilliamsR M Krauss
Dec 1, 1991·Mayo Clinic Proceedings·B A KottkeW H Weidman
Jun 23, 1998·Journal of Clinical Epidemiology·S L KardiaC F Sing
Aug 10, 2001·Pediatric Clinics of North America·D M Styne
Jun 27, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rebecca A SpeckmanBarry I Freedman
Dec 3, 2008·Pediatrics·Vicky Lee NgUNKNOWN Studies of Pediatric Liver Transplantation Research Group

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