The relation between serotonin levels and insufficient blood pressure decrease during night-time in hypertensive patients

Blood Pressure
Ramazan TopsakalMikail Yarlioglues

Abstract

The serotonin levels in thrombocytes are decreased in hypertensive patients. The aim of our study was to investigate the relationship between serotonin levels and insufficient nocturnal blood pressure (BP) decrease (non-dipper) in hypertensive patients. Fifty-six hypertensive patients and 27 healthy control subjects were included in the study. Of the hypertensive patients, 28 were classified as dippers and 28 as non-dippers based on nocturnal BP drops of >10 mmHg and <10 mmHg, respectively. Thrombocyte serotonin levels, serum uric acid, and C-reactive protein (CRP), and urinary albumin/creatinine ratios were analysed. Thrombocyte serotonin levels were measured using an enzyme immunoassay. The thrombocyte serotonin level was 378.9 +/- 69.5 ng/10(9) platelet in the non-dipper group, 424.7 +/- 58.6 ng/10(9) platelet in the dipper group, and 518.1 +/- 35.9 ng/10(9) platelet in the control group. Serotonin levels in the non-dipper group were significantly lower than in the dipper group. Serotonin levels negatively correlated with blood pressure (r = -0.6, p<0.001). CRP concentration in the non-dipper group was higher than in the dipper (4.8 +/- 1.4 vs 3.6 +/- 1.6, p<0.01) and control (2.4 +/- 0.9, p<0.001) groups, and microalbuminur...Continue Reading

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Citations

Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Feb 10, 2012·PloS One·Way K W LauUNKNOWN COPD Study Group of the Hong Kong Thoracic Society
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie W Watts
Nov 22, 2020·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain

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