The relation between the effects of hysterectomy, decidual tissue, prolactin, or luteinizing hormone (LH) and the ability of indomethacin to prevent luteolysis in rats bearing LH-dependent corpora lutea

Endocrinology
J Sanchez-Criado, I Rothchild

Abstract

In adult rats hysterectomized on day 8 of pseudopregnancy, the mean serum progesterone (P) level fell from 88 ng/ml on day 8 to 44 ng/ml on day 15 (n = 61). In response to a single sc injection of 0.5 ml of a specific antiserum to LH (LHAS) on day 10, the P level fell to less than 10 by day 15 in 29 of 33 rats; however, this fall, which was indicative of luteolysis, was briefly interrupted by a return to the control level 36 h after treatment. Indomethacin (400 micrograms, sc) administered 12 h before, during, and 12 h after the LHAS injection prevented the luteolysis that followed the 36 h surge in 10 of 15 rats (P less than 0.001). Treatment with 400 micrograms 2Br-alpha ergocryptine (CB 154), sc, on day 10, with or without indomethacin, however, induced a rapid, uninterrupted, and permanent fall to less than 10 in 13 of 13 rats. Treatment with both LHAS and CB 154 reduced the luteolytic effect of CB 154 (P less than 0.001), and indomethacin treatment combined with both LHAS and CB 154 tended to further reduce the luteolytic effect of CB 154 (P less than 0.01). Hypophysectomy on day 10, however, induced rapid, uninterrupted and permanent luteolysis in all rats (15); this was not affected by indomethacin (7 rats) or LHAS (8 ra...Continue Reading

Citations

Apr 1, 1994·Molecular and Cellular Endocrinology·J Olofsson, P C Leung
Jan 1, 1988·Journal of Pineal Research·J E Sánchez-Criado, R Guisado
Mar 21, 2008·Biology of Reproduction·Raquel González-FernándezJosé Eugenio Sánchez-Criado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.