PMID: 2493805Mar 14, 1989Paper

The relation between thromboxane and prostaglandin synthesis in human decidua tissue: a comparison of eicosanoid synthesis in minced tissue with that in a cell-free preparation

Biochimica Et Biophysica Acta
G AsbóthM Tóth

Abstract

Radiotracer studies and radioimmunoassay measurements demonstrate that minced tissues of human decidua produce chiefly thromboxane B2 (TxB2) (70% of total eicosanoids) and small amounts of prostaglandin F2 alpha (PGF2 alpha) (13%) PGD2 (8%), 6-keto-PGF1 alpha (5%) and PGE2 (4%). Inhibition of thromboxane synthesis with a specific inhibitor (OKY-1581: sodium (E)-3-[4(-3-pyridylmethyl)-phenyl]-2-methyl propenoate) increased prostaglandin formation in general, with the main product being PGF2 alpha (38%), a nonenzymic derivative of PGH2. Crude particulate fractions prepared from the same tissue synthesized two major products from [3H]arachidonate, TxB2 and 6-keto-PGF1 alpha (54 and 30%, respectively) and some PGF2 alpha and PGE2 (8-8%). However, in the presence of reduced glutathione (GSH), PGE2 became the main product (81%) (TxB2, 15%; PGF2 alpha, 2%; and 6-keto-PGF1 alpha, 2%). Half-maximal stimulation of PGE2 synthesis occurred at 46 microM GSH. The GSH concentration of tissue samples was found to be 110 +/- 30 microM. We conclude that human first trimester decidua cells possess the key enzymes of prostaglandin and thromboxane synthesis. Apparently, the production of these compounds is controlled by a specific mechanism in the ...Continue Reading

References

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Citations

Apr 17, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M F KnapenE A Steegers
Jul 25, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Merja VainioJohanna Mäenpää
May 1, 1996·American Journal of Obstetrics and Gynecology·R M van der WeidenM J Keirse
May 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Quadri K AlabiAyowole A Oladele
Nov 13, 2013·Journal of Psycholinguistic Research·Eszter Tisljár-SzabóCsaba Pléh
Aug 1, 2002·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoToshihiko Michimata

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