The relation of agglutinins to antigenic variation of Trypanosoma lewisi
During the course of infection in the rat, Trypanosoma lewisi produces 2 antigenic variants: the 1st represents the initial, reproducing population of cells; and the 2nd the nonreproducing, ablastin-inhibited adult population. The specificities of the agglutinins elicited by the variants were studied by adsorption and agglutination methods and the newer immunoelectroadsorption technic. It was found that the reproducing variant has a surface antigen that reacts with the agglutinin specific for the adult variant, but this antigen does not become immunogenic until transformation to the adult variant occurs. It was also found, with fractions of immune sera obtained by gel filtration, that the agglutinin specific for the reproducing variant is IgG and that specific for the adult variant, IgM. The antigenic variants of pathogenic and nonpathogenic trypanosomes are compared, and the roles of trypanocidal and ablastic antibodies in the induction of antigenic variation are discussed.
A pattern in the development of agglutinogenic antigens of cyclically transmitted isolates of Trypanosoma gambiense
Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c
Spermatogonial stem cell killing in the mouse following single and fractionated x-ray doses, as assessed by length of sterile period
Some properties of the immunogens (protective antigens) of a single variant of Trypanosoma brucei brucei
The presence of agglutinating antibody in the IgM immunoglobulin fraction of rabbit antiserum during experimental African trypanosomiasis
Comparative immunological studies on somatic antigens and secretion-excretion products of blood stream and culture forms of Trypanosoma lewisi. I. Protective immunity and the agglutinin response
A study of cytoplasmic inclusions in Trypanosoma lewisi and their relationship to the formation of antibody
A Study of the Interaction of Host and Parasite: A Reaction Product in Infections with Trypanosoma Lewisi which Inhibits the Reproduction of the Trypanosomes
A REACTION PRODUCT IN INFECTIONS WITH TRYPANOSOMA LEWISI WHICH INHIBITS THE REPRODUCTION OF THE TRYPANOSOMES
Trypanosoma lewisi: antibody classes which mediate precipitation, agglutination, and the inhibition of reproduction
Trypanosoma lewisi: stage-specific surface antigens and exoantigens recognized by monoclonal antibodies
Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.