The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma

Journal of Cancer
Paula Roberta Aguiar PastrezAdhemar Longatto-Filho

Abstract

GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) was found in the same frequency (13.8%) in esophageal squamous cell carcinoma (ESCC) and in healthy individuals. The p53 expression was positive in 67.5% of tumor tissue, 20.0% of adjacent non-tumoral tissue and 1.8% of normal esophageal tissue. p16 was positive in 11.6% of esophageal cancer cases and 4.7% of adjacent non-tumoral tissue. p16 was undetectable among control group samples. p53 and p16 levels were not significantly associated with the HPV status. CONCLUSIONS: These results suggest that hr-HPV types are not associated with the development of ESCC and that p53 and p16 protein expression have no relationship with HPV infection in normal or cancerous esophagus.

Citations

Sep 11, 2019·Pathogens and Disease·Yılmaz BaşMakbule Arar Çıkrıkçıoğlu
Mar 14, 2020·Infectious Agents and Cancer·Sandra F MartinsAdhemar Longatto-Filho
Oct 20, 2017·Infectious Agents and Cancer·Allini Mafra da CostaAdhemar Longatto-Filho
Jun 1, 2018·Annals of the New York Academy of Sciences·Hala El-ZimaityRobert Riddell
Jun 20, 2020·Virchows Archiv : an International Journal of Pathology·Hirotaka IshidaHironobu Sasano
May 20, 2021·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Luiz Filipe Alkamin WoellnerOsvaldo Malafaia
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Javid Sadri NahandHamed Mirzaei

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Methods Mentioned

BETA
biopsies
PCR
genotyping

Software Mentioned

SPSS® Statistics

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