PMID: 7028600Oct 1, 1981Paper

The relation of islet amyloid to the clinical type of diabetes

Human Pathology
A L MaloyE R Greenberg

Abstract

Islets were evaluated for the presence of amyloid deposits in 169 pancreases removed at autopsy. Islet amyloid occurred in 17 of 142 (12 per cent) of nondiabetics and in 16 of 27 (59 per cent) of diabetics. When diabetics were divided into categories according to clinical severity of disease, the insulin treated diabetics had the highest prevalence (89 per cent), the most diffuse distribution, and the most severe degree of islet amyloidosis. Amyloid was not found in any pancreases from subjects under 40 years of age. Above the age of 40, there was no correlation between aging and prevalence of islet amyloid. There was a significant association between severity of diabetes and prevalence of islet amyloid. The low prevalence of amyloid seen in nondiabetics and the fact that all adult onset, insulin treated diabetics had islet amyloid indicate that a reaction to endogenous insulin may be the basis for the deposition of islet amyloid.

Citations

Feb 1, 1993·European Journal of Clinical Investigation·B H Wolffenbuttel, T W Van Haeften
Jun 8, 2000·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·G T Westermark, P Westermark
Jul 10, 2014·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Kosuke KamataSoroku Yagihashi
Mar 29, 2019·Current Protein & Peptide Science·Wei LingHai-Lu Zhao
Jun 22, 2019·The Journal of Membrane Biology·Mikkel Christensen, Birgit Schiøtt
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·H ToshimoriS Matsukura
Jul 1, 1992·Diabetes/metabolism Reviews·A Clark
Mar 6, 2004·Upsala Journal of Medical Sciences·Gunilla T WestermarkArne Andersson
Sep 26, 2008·Pancreas·Hai-Lu ZhaoJuliana C N Chan
Dec 30, 2008·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Stephanie McCainEd Ramsay
Jun 23, 2011·PloS One·Sebastian Wolfgang SchultzGunilla Torstensdotter Westermark
Jul 12, 2011·Physiological Reviews·Per WestermarkGunilla T Westermark
Jan 4, 2017·The Journal of Clinical Investigation·Kosei Eguchi, Ryozo Nagai
Aug 21, 2019·BioMed Research International·Anna Rorbach-Dolata, Agnieszka Piwowar
Apr 1, 1992·Diabetologia·P WestermarkC Betsholtz
Apr 30, 2003·Biopolymers·Alessandro MascioniGianluigi Veglia
Mar 26, 2005·Virchows Archiv : an International Journal of Pathology·Cecilia M BorromeoChristiaan F Van Schravendijk
Jun 17, 2020·Nature Structural & Molecular Biology·Qin CaoDavid S Eisenberg
Apr 28, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ji Young ParkKwang-Won Kim
Feb 26, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·E J de KoningA Clark
Sep 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·A Clark
May 11, 2021·Frontiers in Molecular Biosciences·Mikkel ChristensenBirgit Schiøtt
Jan 1, 1992·Diabetes Research and Clinical Practice·Y TokuyamaS Inoue

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