The relation of leptin and adiponectin with breast density among premenopausal women.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Gertraud MaskarinecRobert V Cooney

Abstract

The adipocytokine leptin may increase breast cancer risk, while adiponectin may be protective. We examined the association of the two circulating markers with mammographic density, a strong predictor of breast cancer risk. For 183 premenopausal participants of a nutritional trial, mammograms performed at baseline, year 1 and year 2 were assessed for density using a computer-assisted method. Serum samples obtained at the same time were analyzed for leptin and adiponectin by enzyme-linked immunosorbent assay. We applied mixed models to incorporate the repeated measurements while adjusting for confounders including body mass index (BMI). At baseline, the mean age of the participants was 42.6+/-2.9 years; 40% were of Asian ancestry. Leptin was lower and adiponectin higher in normal weight than overweight women. Neither marker was related to absolute breast density. The significant inverse association of leptin with percent density disappeared when BMI was added to the model. After stratification by weight, percent density decreased with higher leptin levels in normal weight women, whereas it increased among overweight participants. After adjustment for BMI, the positive association between percent density and adiponectin was greatl...Continue Reading

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Citations

Jul 14, 2010·Medical Oncology·Xiuping Chen, Yitao Wang
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Claire M Perks, Jeff M P Holly
Apr 17, 2014·International Journal of Epidemiology·Debora MacisSara Gandini
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Nov 26, 2014·Cancer Causes & Control : CCC·Maureen SandersonAnthony C Disher
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Apr 9, 2013·The International Journal of Biological Markers·Cher DallalEmanuela Taioli
Dec 22, 2016·Menopause : the Journal of the North American Menopause Society·Mirette HannaCaroline Diorio

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