The relation of motion sickness to the spatial-temporal properties of velocity storage

Experimental Brain Research
Mingjia DaiBernard Cohen

Abstract

Tilting the head in roll to or from the upright while rotating at a constant velocity (roll while rotating, RWR) alters the position of the semicircular canals relative to the axis of rotation. This produces vertical and horizontal nystagmus, disorientation, vertigo, and nausea. With recurrent exposure, subjects habituate and can make more head movements before experiencing overpowering motion sickness. We questioned whether promethazine lessened the vertigo or delayed the habituation, whether habituation of the vertigo was related to the central vestibular time constant, i.e., to the time constant of velocity storage, and whether the severity of the motion sickness was related to deviation of the axis of eye velocity from gravity. Sixteen subjects received promethazine and placebo in a double-blind, crossover study in two consecutive 4-day test series 1 month apart, termed series I and II. Horizontal and vertical eye movements were recorded with video-oculography while subjects performed roll head movements of approx. 45 degrees over 2 s to and from the upright position while being rotated at 138 degrees /s around a vertical axis. Motion sickness was scaled from 1 (no sickness) to an endpoint of 20, at which time the subject w...Continue Reading

Citations

Dec 13, 2005·Experimental Brain Research·Mingjia DaiBernard Cohen
Oct 6, 2006·Experimental Brain Research·James R Lackner, Paul Dizio
Jan 27, 2007·Experimental Brain Research·Mingjia DaiBernard Cohen
May 23, 2008·Experimental Brain Research·Paul Z EliasLaurence R Young
Jul 2, 2008·Experimental Brain Research·Gilles ClémentJean-Hubert Courjon
May 22, 2009·Experimental Brain Research·Mingjia DaiBernard Cohen
Jun 11, 2010·Experimental Brain Research·Mingjia DaiBernard Cohen
Feb 3, 2011·Experimental Brain Research·Mingjia DaiBernard Cohen
Feb 22, 2011·Experimental Brain Research·Jaime MateusLaurence R Young
Dec 31, 2009·Journal of Neurology·Seong-Hae JeongJi Soo Kim
Sep 2, 2008·European Journal of Applied Physiology·Sébastien TanguyPierre Denise
Jan 6, 2007·Biological cybernetics·Isaac Z FosterGin McCollum
Jul 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard CohenDominik Straumann
Jan 11, 2014·Journal of the Association for Research in Otolaryngology : JARO·Andrew J Coniglio, Benjamin T Crane
Dec 3, 2014·Neurologic Clinics·Shin C BehElliot M Frohman
Feb 26, 2016·Frontiers in Neurology·Giovanni Bertolini, Dominik Straumann
Sep 13, 2011·Acta Oto-laryngologica·Kayoko Higashi-ShingaiHidenori Inohara
Nov 27, 2014·Frontiers in Neurology·Susan KingRichard F Lewis
Nov 5, 2016·Journal of Vestibular Research : Equilibrium & Orientation·Jan E HollyChiran S Bhandari
Nov 10, 2017·Current Opinion in Neurology·Alexander A Tarnutzer, Dominik Straumann
Mar 6, 2018·The Cochrane Database of Systematic Reviews·Fiona J RoweHelen Rodgers
Jan 31, 2019·Journal of Neurophysiology·Bernard CohenCatherine Cho
Feb 6, 2018·Journal of Vestibular Research : Equilibrium & Orientation·Jelte E BosP Eric M Vente
Apr 16, 2020·Journal of Neurophysiology·Gilles R ClémentWilliam H Paloski
Jan 19, 2005·Current Opinion in Neurology·John F Golding, Michael A Gresty
May 23, 2017·Frontiers in Neurology·Mingjia DaiSergei B Yakushin
Aug 19, 2018·Experimental Brain Research·Suzanne A E NooijHeinrich H Bülthoff
May 31, 2017·Frontiers in Neurology·Giovanni BertoliniDominik Straumann
Feb 21, 2018·Frontiers in Neurology·Bernard CohenCatherine Cho
Apr 25, 2018·Journal of Vestibular Research : Equilibrium & Orientation·Gilles Clément, Millard F Reschke
Nov 30, 2018·Frontiers in Neurology·Erwin IdouxMathieu Beraneck
Apr 26, 2017·Journal of the Association for Research in Otolaryngology : JARO·Ana Diaz-ArtilesFaisal Karmali
Jul 6, 2020·Journal of Vestibular Research : Equilibrium & Orientation·Justin Maximilian Mittelstaedt
Nov 28, 2020·Frontiers in Neurology·Viviana MucciBruno Burlando
Nov 9, 2018·Deutsches Ärzteblatt International·Andreas KochJohann Peter Kuhtz-Buschbeck
Jan 30, 2021·Frontiers in Neurology·Jun Maruta
Mar 30, 2021·Experimental Brain Research·Tugrul IrmakRiender Happee
Apr 30, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Sebastian WurthmannMark Obermann

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