Abstract
Objectives Endothelial dysfunction is an early marker of vascular disease in Type 1 diabetes mellitus (T1DM). In the present study, we aimed to investigate serum endocan and soluble endoglin (S-endoglin) levels, and their relation with metabolic control in children with T1DM, which was not previously assessed. Methods A total of 64 T1DM subjects and 64 healthy subjects were included in this study. Their anthropometric features, arterial blood pressures, pubertal status, insulin doses were recorded. Glycated hemoglobin, serum endocan and S-endoglin levels were measured and compared to each other. Results Serum endocan and S-endoglin levels were higher in children with T1DM than those of healthy group (p<0.01). Significant positive correlation was detected between both endocan and S-endoglin (r=0.579, p<0.001); and HbA1c and endocan (r=0.296, p=0.01). Compared to patients with good metabolic control, those with poorer metabolic control (HbA1c > 8%) had an older age, longer duration of diabetes, higher number of pubertal children. Also, patients with poorer metabolic control had higher endocan and S-endoglin levels than those of healthy group, but this finding did not reach statistical significance. There was no correlation betwee...Continue Reading
References
Mar 1, 1976·Archives of Disease in Childhood·J M Tanner, R H Whitehouse
Feb 1, 1996·Atherosclerosis·A D BlannS Kumar
Jul 21, 2000·BMJ : British Medical Journal·J DaneshM B Pepys
May 15, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mariapina PomilioFrancesco Chiarelli
May 28, 2005·Diabetes Care·Samar BasuChristian Berne
Dec 22, 2010·BMC Medicine·Ana M Blázquez-MedelaCarlos Martínez-Salgado
Feb 4, 2011·Diabetes Care·Ghufran S BabarRamin Alemzadeh
Oct 30, 2013·Cardiovascular Diabetology·Oliver SchnellAntonio Ceriello
May 30, 2014·Current Eye Research·Ahmed M Abu El-AsrarKarel Geboes
Nov 2, 2014·Immune Network·Young-Saeng Jang, In-Hong Choi
Jan 15, 2015·Genetic Testing and Molecular Biomarkers·Xiang-sheng WangYan-yan Jing
May 15, 2015·Angiology·Yucel ArmanTufan Tukek
Oct 9, 2015·Atherosclerosis·Sevket BaltaAtila Iyisoy
Nov 29, 2015·Angiology·Abdullah IcliAdem Kucuk
Jan 19, 2016·Journal of Clinical Research in Pediatric Endocrinology·Olcay NeyziFirdevs Baş
Feb 20, 2016·Circulation Research·Michael A Gimbrone, Guillermo García-Cardeña
Apr 22, 2016·Journal of Clinical Research in Pediatric Endocrinology·Hamdi Cihan EmeksizPeyami Cinaz
Oct 21, 2016·Renal Failure·Mehmet Ali CikrikciogluReha Erkoc
Dec 15, 2016·Journal of Diabetes Research·Dijana J MiricDragana Puhalo-Sladoje
May 16, 2017·The American Journal of the Medical Sciences·Yaya LvJinxing Quan
Nov 5, 2017·Current Diabetes Reports·Evgenia GourgariKristina Rother
Nov 28, 2017·Angiology·Ilhan BalamirTuran Turhan
May 12, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Cíntia Castro-CorreiaManuel Fontoura
Dec 14, 2018·Medicine·Tianming ZhaoJixiang Ni
Jan 16, 2019·Diabetes & Metabolic Syndrome·Ahmed S DoghishRania Y Zakaria
Jan 31, 2019·Archives of Medical Science : AMS·Betül Ekiz-BilirNeslihan Soysal-Atile
Jun 15, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ying ZhangPin Li
Oct 28, 2019·Cardiovascular Endocrinology & Metabolism·Alicia JenkinsDavid O'Neal
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association
Feb 23, 2020·Angiology·Ana Rita LeiteAdelino Leite-Moreira