Abstract
The objective was to investigate the relationship of systemic hypertension to the incidence of various retinal vascular lesions in the population-based Beaver Dam Eye Study. Subjects aged 43 through 86 years who lived in Beaver Dam, Wisconsin between 1987 and 1988 were examined between 1988 and 1990 and 5 years later, 1993-1995. Blood pressure was measured using standardized protocols. Stereoscopic color fundus photographs were graded in a masked fashion using standardized protocols to determine the presence of retinopathy (blot hemorrhages, microaneurysms, hard and soft exudates, intraretinal microvascular abnormalities, and venous beading), retinal arteriolar narrowing, and arterio-venous nicking. People with diabetes or retinal vascular occlusions were excluded from the analyses. Among those examined, 2,151 (69.1%) were normotensive and 963 (30.9%) were hypertensive at baseline. Over the five-year period, retinopathy developed in 175 (6.0%), arteriolar narrowing in 282 (9.9%) and arterio-venous nicking in 201 (6.5%) nondiabetic subjects. After adjusting for age, hypertension was associated with the incidence of retinopathy (in men: relative risk [RR] 2.31, 95% confidence interval [CI] 1.54 to 3.48; in women: RR 1.61, 95% CI ...Continue Reading
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