The Relations Among Serum Ghrelin, Motilin and Gastric Emptying and Autonomic Function in Autoimmune Gastritis

The American Journal of the Medical Sciences
Çağdaş Kalkan, Irfan Soykan

Abstract

Gastric emptying (GE) of solids is delayed and autonomic dysfunction is detected in autoimmune gastritis (AIG). The goals of this study were to: (1) compare serum levels of ghrelin and motilin in subjects with delayed and normal GE and (2) investigate whether circulating antimyenteric antibodies (CAA), serum ghrelin levels and motilin levels have any effect on autonomic function. Noninvasive cardiovascular reflex tests were used in order to evaluate the autonomic function. GE was evaluated by a standard 2-hour scintigraphic test. Serum ghrelin and motilin levels were tested by enzyme-linked immunosorbent assay and CAA were tested by immunofluorescence. The serum ghrelin and motilin levels in the patients with delayed GE (n = 22) were significantly decreased compared to the normal GE patients (n = 19), (67.55 ± 8.81 versus 126.79 ± 25.81pg/mL, P < 0.001 and 279.59 ± 111.12 versus 500.42 ± 155.95pg/mL, respectively, P < 0.001). Whereas, the serum ghrelin and motilin levels in the patients with deranged autonomic function (n = 26) were significantly decreased compared to the patients with normal autonomic function (n = 15), (80.73 ± 28.46 versus 127.79 ± 28.06pg/mL, P < 0.001 and 316.92 ± 160.47 versus 490.20 ± 141.02pg/mL, P < 0....Continue Reading

References

Apr 24, 1976·Lancet·P MitzneggL Demling
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Jan 1, 1997·Peptides·Z Itoh
Jul 14, 2006·Digestive Diseases and Sciences·Koji YakabiKiyoshige Takayama
Aug 23, 2007·The Journal of Clinical Endocrinology and Metabolism·Serenella ChecchiFurio Pacini
Dec 7, 2007·European Journal of Endocrinology·Núria AlonsoAnna Sanmartí
Apr 16, 2008·Rheumatology·T MandlL T H Jacobsson
Jul 9, 2008·World Journal of Gastroenterology : WJG·Zhen-Hai ZhangHao-Lin Wang
Oct 24, 2008·Endocrine Journal·Shiko AsaiYasushi Tanaka
May 13, 2009·Nature Reviews. Gastroenterology & Hepatology·Michael CamilleriSuwebatu T Odunsi
Aug 25, 2009·Journal of Gastroenterology·Junichi KawashimaKoji Yakabi
Sep 6, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M Kallel-SellamiS Makni
Dec 4, 2012·Gastrointestinal Endoscopy·Jason Y ParkRoopa Vemulapalli
Jun 19, 2013·Nature Reviews. Gastroenterology & Hepatology·William L NeumannRobert M Genta
Oct 24, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah MarrinanDavid J Burn
Sep 24, 2015·Nature Reviews. Gastroenterology & Hepatology·Gareth J Sanger, John B Furness
Oct 30, 2015·Scandinavian Journal of Gastroenterology·Suh Eun BaeHwoon-Yong Jung
Nov 18, 2015·World Journal of Gastroenterology : WJG·Irene CoatiMassimo Rugge
Jan 5, 2016·Digestive Diseases and Sciences·Çağdaş KalkanEmra Kalkan
Apr 10, 2016·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Çağdaş KalkanIrfan Soykan

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Citations

Jul 28, 2019·International Journal of Cancer. Journal International Du Cancer·Natalie R PritchettGwen Murphy

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