PMID: 11904589Mar 21, 2002Paper

The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea

American Journal of Obstetrics and Gynecology
Jung Gu KimJin Yong Lee

Abstract

The objective of this study was to test the hypothesis that the cytosine-adenine polymorphism in the insulin-like growth factor-I gene is associated with serum insulin-like growth factor-I levels and bone mineral density. The insulin-like growth factor-I cytosine-adenine polymorphism was analyzed in 300 postmenopausal Korean women. Serum insulin-like growth factor-I, bone alkaline phosphatase, and carboxy-terminal cross-linking telopeptide of type I collagen were measured by immunoradiometric assay and enzyme-linked immunosorbent assay. Bone mineral density at the lumbar spine and proximal femur was determined by dual energy radiograph absorptiometry. Serum insulin-like growth factor-I and bone mineral density levels in women who were homozygous for a 194-base pair allele were significantly higher than those levels in the 194-base pair heterozygotes or women who did not possess the 194-base pair allele. A significantly decreased prevalence of the 194/194 genotype was observed in the combined group of women with osteopenia and osteoporosis, compared with normal women. No correlation between insulin-like growth factor-I genotypes and bone turnover markers was found. The insulin-like growth factor-I gene cytosine-adenine polymorph...Continue Reading

Citations

Dec 20, 2005·Journal of Korean Medical Science·Jung Gu KimShin Yong Moon
Nov 23, 2010·American Journal of Physical Anthropology·Robin M Bernstein
Jul 9, 2010·Menopause : the Journal of the North American Menopause Society·Dong-Yun LeeJung Gu Kim
Jun 14, 2013·Menopause : the Journal of the North American Menopause Society·Hee Jun LeeJung Gu Kim
Oct 1, 2014·Menopause : the Journal of the North American Menopause Society·Jae Hee WooJung Gu Kim
Aug 25, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ming GuanYinshuang Zou
Jun 18, 2004·Current Opinion in Rheumatology·P A Baldock, John A Eisman
Jun 1, 2006·Menopause : the Journal of the North American Menopause Society·Jung Gu KimShin Yong Moon
May 12, 2018·BMC Musculoskeletal Disorders·Shu-Tao GaoWei-Bin Sheng
Jul 15, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bonghan Lee, Kijin Kim
Apr 15, 2015·Menopause : the Journal of the North American Menopause Society·Eun Hee ChunJung Gu Kim
Nov 25, 2003·Menopause : the Journal of the North American Menopause Society·Jung Gu KimJin Yong Lee
Oct 16, 2010·International Journal of Hypertension·Francesca Marini, Maria Luisa Brandi
Nov 18, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Masanobu Kawai, Clifford J Rosen
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul

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