PMID: 951464Apr 15, 1976

The relationship between acetylator status and inhibition of monoamine oxidase, excretion of free drug and antidepressant response in depressed patients on phenelzine

Psychopharmacologia
E C Johnstone

Abstract

This study was designed to examine the hypothesis that phenelzine is metabolized by polymorphic acetylation and that its effects are dependent on acetylator status. 30 depressed inpatients were given a 3-week course of phenelzine 30 mg t.i.d. The antidepressant effect, the degree of inhibition of monoamine oxidase and the amount of free phenelzine excreted in the urine were all significantly greater in slow acetylators than in fast. These findings strongly support the hypothesis.

References

Mar 17, 1973·Lancet·E C Johnstone, W Marsh
Aug 26, 1972·British Medical Journal·H Schröder
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Citations

Feb 28, 1979·Psychopharmacology·W J TilstoneE C Johnstone
Jan 1, 1988·Journal of Psychiatric Research·P Tyrer, C Shawcross
Jan 1, 1980·Progress in Neuro-psychopharmacology·C Q MountjoyM Roth
Sep 1, 1978·British Journal of Clinical Pharmacology·E F MarshallM Roth
May 1, 1979·British Journal of Clinical Pharmacology·G L Sanders, M D Rawlins
Jun 1, 1976·British Journal of Pharmacology·D Blatchford, M Holzbauer
Jul 10, 1976·British Medical Journal
Oct 2, 1976·British Medical Journal·E F Marshall
Nov 4, 1978·Lancet·J A Lee
Aug 1, 1991·Journal of Pharmaceutical Sciences·R T CouttsG B Baker
May 7, 2002·The Pharmacogenomics Journal·N J ButcherR F Minchin
Jan 1, 1981·Journal of Neural Transmission·H W Moises, H Beckmann
Apr 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·P TyrerM Whitford
Sep 14, 2006·Pharmacological Reviews·Sharon J Gardiner, Evan J Begg
Jun 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·C M PARE

Related Concepts

Acetylation
Depressive Symptoms
Monoamine Oxidase
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Nardelzine
Triptans

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