Abstract
Whether in man histamine (H) and acetylcholine (ACH) airway responses are interrelated is controversial. With the use of quantitative nebulization and specific airway conductance (Gaw/VL), we recorded noninvasive pharmacologic tests of H- and ACH-induced bronchoconstriction in 11 normal subjects (N) and nine subjects with asthma (AST) with and without pretreatment of 0.75 mg (A0.75) and 1.50 mg (A1.50) of inhaled atropine. Provocation dose 40 (PD40) for H or ACH were different in N (0.8 X 10(-2) mol/L and 2.9 X 10(-2) mol/L, respectively) and AST (5.0 X 10(-3) mol/L and 7.8 X 10(-3) mol/L) but linearly related. The ratio PD40-ACH/PD40-H was comparable in N and AST and similar to the ratio ACH sensitivity/H sensitivity found in vitro for large airways. The slopes of log dose-response curves (SLDRC) to H and SLDRC to ACH were of similar magnitude both in N and AST and linearly related; however, for either agonist, bronchial sensitivity (PD40) and reactivity (SLDRC) failed to correlate. After A0.75, the dose ratios (DR) of H and ACH were large, with substantial intersubject variability, and similar in N (4.32 and 9.54, respectively) and AST (5.97 and 5.64). Although numerically comparable, DR of H and DR of ACH were unrelated. Aft...Continue Reading
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