The Relationship Between Actin Cytoskeleton and Membrane Transporters in Cisplatin Resistance of Cancer Cells

Frontiers in Cell and Developmental Biology
Takahiro ShimizuHideki Sakai

Abstract

Cisplatin [cis-diamminedichloroplatinum (II)] is a platinum-based anticancer drug widely used for the treatment of various cancers. It forms interstrand and intrastrand cross-linking with DNA and block DNA replication, resulting in apoptosis. On the other hand, intrinsic and acquired cisplatin resistance restricts its therapeutic effects. Although some studies suggest that dramatic epigenetic alternations are involved in the resistance triggered by cisplatin, the mechanism is complicated and remains poorly understood. Recent studies reported that cytoskeletal structures regulate cisplatin sensitivity and that activities of membrane transporters contribute to the development of resistance to cisplatin. Therefore, we focus on the roles of actin filaments and membrane transporters in cisplatin-induced apoptosis. In this review, we summarize the relationship between actin cytoskeleton and membrane transporters in the cisplatin resistance of cancer cells.

References

Nov 1, 1994·The Journal of Membrane Biology·S FatheraziC M Belton
Oct 1, 1995·The Journal of Membrane Biology·I LevitanS S Garber
Nov 14, 1997·The American Journal of Physiology·J ZhangM Lieberman
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Lebwohl, R Canetta
Feb 6, 1999·The Journal of Biological Chemistry·S C Posey, B E Bierer
Aug 24, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·M Suzuki, J D Gitlin
Dec 3, 1999·Biochimica Et Biophysica Acta·P BorstJ Wijnholds
Mar 23, 2000·Cardiovascular Research·A Saraste, K Pulkki
Jul 6, 2000·The Japanese Journal of Physiology·S MorishimaY Okada
Jul 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·E MaenoY Okada
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·S R WhiteD R Dorscheid
Jul 21, 2001·Molecular Cell·K Nakano, K H Vousden
Jan 11, 2002·Molecular and Cellular Biology·Catherine PaulAndré-Patrick Arrigo
Apr 12, 2002·Journal of Neurochemistry·Yuanbin LiuDavid Schubert
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiko IshidaIra Herskowitz
Oct 23, 2002·Molecular Pharmacology·Xinjian LinStephen B Howell
Oct 24, 2002·Human Molecular Genetics·Christian CobboldAnthony P Monaco
Oct 29, 2002·Nature Cell Biology·Joanna K SaxWafik S El-Deiry
Oct 3, 2003·The Biochemical Journal·Pontus AspenströmJan Saras
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takahiro ShimizuYasunobu Okada
Nov 30, 2005·The American Journal of Pathology·Giuliano CiarimboliEberhard Schlatter
Sep 7, 2006·Nature Reviews. Drug Discovery·Jessica E BoldenRicky W Johnstone
Nov 28, 2006·Nature Reviews. Cancer·Franck Toledo, Geoffrey M Wahl
Dec 23, 2006·Journal of Cellular Physiology·Elbert L LeeYasunobu Okada
Feb 21, 2007·Nature Structural & Molecular Biology·Mingxuan Xia, Hartmut Land
May 15, 2007·Oncogene·A S DhillonW Kolch
May 17, 2007·Apoptosis : an International Journal on Programmed Cell Death·Paloma BragadoAlmudena Porras
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lainie P MartinRussell J Schilder
Apr 23, 2008·The Journal of Cell Biology·Youssef H ZeidanYusuf A Hannun
Jul 16, 2008·Cancer Chemotherapy and Pharmacology·Dawn P G BrownMu Wang
Oct 23, 2009·American Journal of Physiology. Cell Physiology·K A PoulsenE K Hoffmann
Feb 18, 2010·Molecular Pharmacology·Stephen B HowellMichael J Sailor
Mar 6, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amélie RebillardMarie-Thérèse Dimanche-Boitrel

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Citations

Mar 2, 2021·Frontiers in Cell and Developmental Biology·Chengyi MaoYong Yuan

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Methods Mentioned

BETA
GTPase
GTPases

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