PMID: 6168873Jan 1, 1981Paper

The relationship between aging and ribosomal gene activity in humans as evidenced by silver staining

Mechanisms of Ageing and Development
T E DentonJ V Barrett

Abstract

Silver selectively stains nucleolar organizer regions (NORs) distributed on the D and G chromosomes of man. The number of NORs is fairly constant for a given individual but is highly variable within populations. When 2540 metaphases from lymphocytes were examined from 127 normal subjects, a mean NOR number of 7.3 was obtained with a mode of 7. No significant difference was found in mean NOR number between females and males. However, regression lines do show a decrease in NOR number with aging for both sexes but the rate of decline is more evident in females. Also, G chromosome NORs appear more stable than those in D chromosomes. Since silver--NOR staining is indicative of ribosomal gene activity, it is proposed that lymphocyte rDNA becomes less sensitive to phytohemagglutinin stimulation during aging. It is unique that this gene repression can be visualized with conventional staining and light microscopy.

References

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Citations

Dec 1, 1984·Mechanisms of Ageing and Development·T A Lezhava
Sep 1, 1986·Mechanisms of Ageing and Development·D L DoggettT Makinodan
Jan 1, 1989·Mechanisms of Ageing and Development·M G Butler, J R Lane
Dec 1, 1990·Cancer Genetics and Cytogenetics·K KurvinkL Porzucek
Feb 1, 1992·International Journal of Immunopharmacology·W VormittagV Scheiber
Jan 1, 1986·Experimental Gerontology·B L Strehler
Jan 1, 1991·Experimental Gerontology·T MakinodanA Iida-Klein
Apr 3, 2009·Micron : the International Research and Review Journal for Microscopy·Halil Demirtas
Aug 20, 2005·Gerontology·Hamiyet Dönmez-AltuntaşYusuf Ozkul
Mar 9, 2019·Reviews in the Neurosciences·Caitlin NyhusVanessa Jane Hall
Apr 1, 1989·Clinical Genetics·J E GreenB J White
Feb 1, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L HéliotY Usson
Mar 14, 2013·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R ErozN Cucer

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