The relationship between baseline exhaled nitric oxide levels and acute mountain sickness

The American Journal of the Medical Sciences
Xue-Wen RenPing Ye

Abstract

Acute mountain sickness (AMS) is a common disabling condition observed in people ascending to high altitudes. However, a simple predictive test for AMS is not known. The aim of this study was to assess the relationship between baseline exhaled nitric oxide (FENO) and AMS occurrence. Eighty healthy lowland Chinese adults were recruited for this study. FENO was measured at baseline, as well as 6 and 24 hours after arrival in Tibet. The standard Lake Louise Score (LLS) consensus symptoms questionnaire was used to assess the incidence and severity of AMS. Individuals with a high LLS (> 3) had higher FENO levels at baseline and after arrival in Tibet than people with a low LLS (≤ 3) (baseline: 22.9 ± 11.9 versus 16.7 ± 6.4; 6 hours: 26.2 ± 16.7 versus 17.9 ± 5.7; 24 hours: 24.9 ± 13.1 versus 16.3 ± 1.7; all P < 0.01). Evaluation of risk factors revealed that female gender, diabetes and not smoking were associated with a high AMS score (all P < 0.05), but that hypertension showed no association (P > 0.05). This prospective observational study suggests that baseline FENO levels may be positively correlated with AMS in healthy Chinese lowlanders.

References

Dec 16, 1991·Biochemical and Biophysical Research Communications·L E GustafssonS Moncada
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·T BuschE R Swenson
Jul 14, 2001·The New England Journal of Medicine·P H Hackett, R C Roach
Nov 24, 2001·Nature·C M BeallS C Erzurum
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Karin Storm van's GravesandeJeffrey M Drazen
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keith R BurgessJackie Cooper
Feb 24, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Daniel E BrownPhoebe S Mills
Aug 15, 2006·Cardiovascular Research·Marco Maggiorini
Nov 7, 2007·Circulation·Peter Bärtsch, J Simon R Gibbs
Oct 17, 2008·Aviation, Space, and Environmental Medicine·Johnny Conkin, James H Wessel
Jan 24, 2009·Lancet Neurology·Mark H WilsonChris H Imray
Aug 19, 2009·Respiratory Physiology & Neurobiology·Tryggve Hemmingsson, Dag Linnarsson
Sep 23, 2009·Respiratory Physiology & Neurobiology·Bengt Kayser
Apr 27, 2010·Progress in Cardiovascular Diseases·Urs ScherrerClaudio Sartori
Nov 30, 2010·Respiratory Physiology & Neurobiology·Denis VinnikovKalysbubu Jumabaeva
Dec 31, 2010·High Altitude Medicine & Biology·Martin J MacInnisJim L Rupert
Apr 26, 2011·Respiratory Physiology & Neurobiology·J DonnellyD R Taylor
Oct 16, 2012·Wilderness & Environmental Medicine·Haiyan YouYuqi Gao
Nov 9, 2012·Medicine and Science in Sports and Exercise·Beth A BeidlemanStephen R Muza
Sep 28, 2013·Experimental Lung Research·Marios KougiasPanagiotis K Behrakis

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Citations

Oct 1, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Denis VinnikovCraig Steinmaus
May 12, 2018·Military Medical Research·Yu WuYong-Jun Luo
Dec 10, 2019·Military Medical Research·Yun-Peng HouYong-Jun Luo

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