The relationship between cardiometabolic and hemostatic variables: influence of race

Metabolism: Clinical and Experimental
Arlette PerryLoreto Jackson

Abstract

Elevated concentrations of hemostatic variables such as fibrinogen, plasma activator inhibitor 1 (PAI-1), and tissue plasminogen activator (t-PA)/PAI-1 complex have been implicated in the pathogenesis of arterial lesion progression and subsequent cardiovascular disease. In the present study, traditional cardiometabolic variables (CMV) associated with cardiovascular disease risk were examined in relation to hemostatic variables in a group of 36 White American (WA) and 30 African American (AA) overweight/obese women. There were 9 CMV significantly related to PAI-1 and/or the t-PA/PAI-1 ratio, but not fibrinogen. A significant race effect was found for 5 CMV in relation to fibrinogen and/or the t-PA/PAI-1 ratio, but not PAI-1. Significant race and high-density lipoprotein cholesterol interactions were found for fibrinogen (P = .021); and significant race and waist to hip ratio (P = .015), diastolic blood pressure (P = .013), and insulin (P = .037) interactions were found for PAI-1. No interactions were found for the t-PA/PAI-complex. Both PAI-1 and the t-PA/PAI-1 ratio are favored above fibrinogen in the diagnostic evaluation of health risk in both WA and AA women. Because of differences by race, independent consideration should b...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Apr 1, 1995·The American Journal of Clinical Nutrition·J M ConwayV S Hubbard
Aug 1, 1993·Metabolism: Clinical and Experimental·B J Potter van LoonA E Meinders
Jan 1, 1993·Medicine and Science in Sports and Exercise·R S PaffenbargerR T Hyde
Jul 1, 1996·Atherosclerosis·I Juhan-Vage
Jul 1, 1997·Diabetes Care·S M HaffnerM P Stern
May 12, 2000·JAMA : the Journal of the American Medical Association·F L BrancatiM Szklo
Sep 12, 2000·Current Cardiology Reports·I Juhan-VagueM Christine Alessi
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Sep 6, 2003·The American Journal of Cardiology·Steven M Haffner
May 1, 1994·Obesity Research·L L DargaC P Lucas

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Citations

Feb 2, 2017·Stroke; a Journal of Cerebral Circulation·Fianne H SpaanderUNKNOWN Thrombolysis in Ischemic Stroke Patients Collaborators (TrISP)

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