Abstract
Elevated concentrations of hemostatic variables such as fibrinogen, plasma activator inhibitor 1 (PAI-1), and tissue plasminogen activator (t-PA)/PAI-1 complex have been implicated in the pathogenesis of arterial lesion progression and subsequent cardiovascular disease. In the present study, traditional cardiometabolic variables (CMV) associated with cardiovascular disease risk were examined in relation to hemostatic variables in a group of 36 White American (WA) and 30 African American (AA) overweight/obese women. There were 9 CMV significantly related to PAI-1 and/or the t-PA/PAI-1 ratio, but not fibrinogen. A significant race effect was found for 5 CMV in relation to fibrinogen and/or the t-PA/PAI-1 ratio, but not PAI-1. Significant race and high-density lipoprotein cholesterol interactions were found for fibrinogen (P = .021); and significant race and waist to hip ratio (P = .015), diastolic blood pressure (P = .013), and insulin (P = .037) interactions were found for PAI-1. No interactions were found for the t-PA/PAI-complex. Both PAI-1 and the t-PA/PAI-1 ratio are favored above fibrinogen in the diagnostic evaluation of health risk in both WA and AA women. Because of differences by race, independent consideration should b...Continue Reading
References
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Dec 1, 1991·Atherosclerosis·A R FolsomM Szklo
Jul 1, 1991·Diabetologia·I Juhan-VagueP Vague
Mar 1, 1986·Metabolism: Clinical and Experimental·P VagueD Collen
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Apr 1, 1995·The American Journal of Clinical Nutrition·J M ConwayV S Hubbard
Aug 1, 1993·Metabolism: Clinical and Experimental·B J Potter van LoonA E Meinders
Jan 1, 1993·Medicine and Science in Sports and Exercise·R S PaffenbargerR T Hyde
Jul 1, 1996·Atherosclerosis·I Juhan-Vage
Aug 23, 1996·Atherosclerosis·A G BostomI H Rosenberg
Jul 1, 1997·Diabetes Care·S M HaffnerM P Stern
Aug 19, 1997·Circulation·A R FolsomL E Chambless
Nov 24, 1998·Circulation·A M ThögersenG Hallmans
May 12, 2000·JAMA : the Journal of the American Medical Association·F L BrancatiM Szklo
Aug 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·B WimanU deFaire
Sep 12, 2000·Current Cardiology Reports·I Juhan-VagueM Christine Alessi
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Mar 28, 2002·Diabetes·Andreas FestaUNKNOWN Insulin Resistance Atherosclerosis Study
Sep 6, 2003·The American Journal of Cardiology·Steven M Haffner
May 1, 1994·Obesity Research·L L DargaC P Lucas
Citations
Apr 26, 2011·AIDS·Takara L StanleySteven K Grinspoon
Jul 11, 2012·Endocrinology·Victoria J Vieira PotterAndrew S Greenberg
Jan 28, 2010·The American Journal of Cardiology·Robert D McBaneUNKNOWN BARI 2D Study Group
Feb 2, 2017·Stroke; a Journal of Cerebral Circulation·Fianne H SpaanderUNKNOWN Thrombolysis in Ischemic Stroke Patients Collaborators (TrISP)
May 16, 2013·Stroke; a Journal of Cerebral Circulation·Pitchaiah MandavaThomas A Kent