The relationship between CD27 negative and positive B cell populations in human peripheral blood.

Frontiers in Immunology
Yu-Chang Bryan WuDeborah K Dunn-Walters

Abstract

CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells are seen in healthy adults, and these are increased in some autoimmune diseases and in the elderly. Thus CD27 is not a universal marker of memory B cells in humans. Various hypotheses have been put forward as to the function of the CD27- memory population. Since we have previously found high-throughput IGHV repertoire analysis useful to distinguish "innate-like" memory B cells (CD27+IgD+), we have employed similar analyses to elucidate the relationship between CD27- and CD27+ memory B cells. IgM+IgD- memory cells in both the CD27+ and CD27- compartments share the unique characteristics of the "innate-like" IgM+IgD+CD27+ cells. The switched CD27+ and CD27- memory cells share a similar IGHV repertoire, having more in common with each other than with "innate-like" memory cells, although it is interesting that IgG2 and IgA2 subclasses of antibody in both switched memory populations have a more "innate-like" repertoire. Clonality analysis shows evidence of a close clonal relationship between the two populations in that both CD27- and CD27+ switched memory cells can be found in t...Continue Reading

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Methods Mentioned

BETA
flow cytometry
PCR

Software Mentioned

QUEST
Laser Gene
DNAstar
ProtParam

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