The relationship between changing values of pregnancy-associated plasma protein-A in late pregnancy and the onset of labour

Placenta
R SmithW Cooper

Abstract

The pattern of change of PAPP-A was established in three separate groups of patients. Day-to-day change from the 38th week was measured in six healthy patients whose pregnancies ended in spontaneous labour. The slow fluctuations of PAPP-A suggest that values found in labour are a consequence of events prior to the onset of labour. Increases of PAPP-A during the last few days of pregnancy and into labour were compared in patients going into labour spontaneously and patients who were induced. The induced patients showed a sharper increase in PAPP-A during this interval than the spontaneous onset group. A comparison at an earlier stage of pregnancy of PAPP-A increase was made between normal pregnancies going into labour on or before 280 days and those who went into labour later. Between 31 +/- 1 and 35 +/- 1 weeks, those who delivered in the earlier group showed a sharper rise in PAPP-A. It seems likely that the behaviour of PAPP-A in late pregnancy is the consequence of uterine activity and it seems unlikely that an increasing level of PAPP-A in itself has anything to do with the initiation of spontaneous labour.

References

Nov 1, 1979·British Journal of Obstetrics and Gynaecology·R SmithA Klopper
Sep 1, 1974·The Journal of Clinical Investigation·T M LinW N Spellacy
Sep 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·A M ThomsonF E Hytten

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Citations

Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jun 1, 1996·Journal of the American College of Nutrition·A D Garnica, W Y Chan

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