The relationship between clinical stage, prognosis and myocardial damage in patients with Duchenne-type muscular dystrophy: five-year follow-up study

Annals of Nuclear Medicine
Hitoshi NaruseKenji Jinnai

Abstract

The evaluation of myocardial damage by [123I] 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) imaging, which represents free fatty acid metabolism, has not been reported in patients with Duchenne-type muscular dystrophy (DMD). To date, the relationship between clinical stage, prognosis and myocardial damage has not been evaluated by radionuclear cardiac imaging. The main goal of this study was to elucidate the relationship of quantitative indices of myocardial damage obtained by radionuclear cardiac imaging ([201Tl] and [123I] BMIPP) to clinical stage and incidence of severe cardiac events in patients with Duchenne-type muscular dystrophy (DMD). The study population consisted of 28 male patients with DMD. The average age at the beginning of observation was 19.1 +/- 7.4 yrs. Nuclear tomographic imaging was performed using [201Tl] and [123I] BMIPP. The mid-ventricular short axial slices were classified into four anatomical regions, and the normalized count data in these areas (TL, BM) were obtained. The endpoint was the occurrence of heart failure during the follow up period. Thirteen cases of heart failure occurred during the 5-year follow-up period, including three cases with cardiac death due to congestive heart fai...Continue Reading

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Citations

Jun 30, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nagara TamakiYuko Kawai
Nov 10, 2012·Physical Medicine and Rehabilitation Clinics of North America·Hugh D AllenJerry R Mendell
Sep 23, 2009·Journal of Molecular and Cellular Cardiology·Yan BurelleChristine Des Rosiers
Jun 23, 2007·Journal of Molecular and Cellular Cardiology·Maya KhairallahChristine Des Rosiers
May 13, 2009·Journal of the American Academy of Nurse Practitioners·Rita Wen KasparFederica Montanaro

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