The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox)

PLoS Neglected Tropical Diseases
Ana Maria Moura-da-SilvaWuelton Marcelo Monteiro

Abstract

Snake venoms are complex mixtures of proteins with toxic activities, with many distinct isoforms, affecting different physiological targets, comprised in a few protein families. It is currently accepted that this diversity in venom composition is an adaptive advantage for venom efficacy on a wide range of prey. However, on the other side, variability on isoforms expression has implications in the clinics of human victims of snakebites and in the efficacy of antivenoms. B. atrox snakes are responsible for most of the human accidents in Brazilian Amazon and the type and abundance of protein families on their venoms present individual variability. Thus, in this study we attempted to correlate the individual venom proteome of the snake brought to the hospital by the patient seeking for medical assistance with the clinical signs observed in the same patient. Individual variability was confirmed in venoms of the 14 snakes selected for the study. The abundance of each protein family was quite similar among the venom samples, while the isoforms composition was highly variable. Considering the protein families, the SVMP group presented the best correlation with bleeding disorders and edema. Considering individual isoforms, some isoforms...Continue Reading

References

Feb 1, 1993·Journal of Protein Chemistry·A C CintraJ R Giglio
Jan 1, 1996·Advances in Experimental Medicine and Biology·W BodeW Stöcker
Mar 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R OteroC A Giraldo
Jul 22, 1999·Toxicon : Official Journal of the International Society on Toxinology·H C CastroR B Zingali
Jun 22, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jorge Luis López-LozanoLauro Morhy
Sep 25, 2003·Toxicon : Official Journal of the International Society on Toxinology·Mónica María SaldarriagaJosé María Gutiérrez
Jan 2, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Pedro Pereira de Oliveira PardalDavid A Warrell
Feb 6, 2004·Toxicon : Official Journal of the International Society on Toxinology·Isabelle TanjoniAna Maria Moura-da-Silva
Mar 31, 2004·Toxicon : Official Journal of the International Society on Toxinology·Alexandra RucavadoJosé María Gutiérrez
May 19, 2005·Biological Chemistry·Mirta SchattnerAna Marisa Chudzinski-Tavassi
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·I TanjoniA M Moura-da-Silva
May 13, 2006·Proteome Science·Rafael A P GuércioCarlos A O Ricart
Jul 12, 2012·Toxicon : Official Journal of the International Society on Toxinology·Bruno Lomonte, José Rangel
Sep 27, 2012·Toxicon : Official Journal of the International Society on Toxinology·Solange M T Serrano
Sep 27, 2013·PLoS Neglected Tropical Diseases·Leijiane F SousaAna M Moura-da-Silva
Jun 11, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Esaú Samuel FeitosaWuelton Marcelo Monteiro
Apr 4, 2018·The American Journal of Tropical Medicine and Hygiene·Jose Diego de Brito SousaWuelton Marcelo Monteiro
Apr 6, 2018·Journal of Proteomics·Diana R AmazonasAna M Moura-da-Silva
Sep 28, 2018·The International Journal of Biochemistry & Cell Biology·Maria-Inacia Estevão-CostaJohannes A Eble
Apr 17, 2019·Toxicon : Official Journal of the International Society on Toxinology·Tiago H Moretto Del-ReiAna M Moura-da-Silva

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Citations

Jan 28, 2021·Toxicon : Official Journal of the International Society on Toxinology·Ricardo S P PatiñoJosé R Almeida
Oct 31, 2020·International Journal of Biological Macromolecules·Chunlin YuPengcheng Li

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