The relationship between coagulation abnormality and mortality in ICU patients: a prospective, observational study

Scientific Reports
Aihua FeiShuming Pan

Abstract

We conducted a prospective, observational study to assess the prognostic value of hemostasis-related parameters in unselected ICU patients. We collected baseline characteristics from 497 consecutive unselected medical and trauma patients during their ICU stay. Each hemostasis-related parameter was analyzed alone or combined with APACHE II scores for any association with ICU mortality by calculating the under the curve (AUC) of the ROC curve, the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) indices. Of all hemostasis-related indicators examined, the AUC for fibrin degradation products (FDPs) was less than that for APACHE II scores, but larger than that for disseminated intravascular coagulation (DIC) scores. The prediction power of FDPs is relatively low. Multiple regression analysis revealed that FDPs and APACHE II scores significantly predicted primary outcome. The combined use of FDPs level and APACHE II scores generated an NRI of 9.94% and an IDI of 3.54%. In conclusion, FDP is the best independent indicator of ICU mortality among all hemostasis-related indicators examined. The use of FDP level and APACHE II scores in parallel significantly improves the ability to predict ICU mortali...Continue Reading

References

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Citations

Feb 19, 2017·Journal of Clinical Laboratory Analysis·Tuncay KırışAbdullah Dogan
Sep 13, 2018·International Journal of Laboratory Hematology·Wiralpat PadungmaneesubRungrote Natesirinilkul
Jan 4, 2020·Acta Anaesthesiologica Scandinavica·Sigurdur BenediktssonThomas Kander

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Methods Mentioned

BETA
dissection
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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