Abstract
The histological similarities seen in Wilson's disease (WD) and non-alcoholic steatohepatitis (NASH) led us to verify possible correlations between glucose and/or lipid and/or iron metabolism alterations and hepatic steatosis in WD patients. Thirty-five WD patients (20 females, 15 males, mean age 40.1 ± 5.4 years), and 44 NASH patients (25 females, 19 males, mean age 42.8 ± 6.7 years) were enrolled in the study. BMI, total/HDL/LDL-cholesterol, triglycerides and glucose serum levels were established in all subjects. HOMA index was calculated. Percutaneous liver biopsy with quantitative evaluation of steatosis and copper tissue content was performed in all WD patients and in NASH control group. Significant difference was seen in baseline serum levels of glucose, HOMA index, total cholesterol, triglycerides, and ferritin between the WD group and NASH group (P<0.05) but steatosis scored was similar between two groups. No correlation between the level of steatosis and metabolic factors studied was highlighted. In WD, hepatic parenchymal copper concentration was 753 ± 65.3 mcg/g dry weight against 54.5 ± 16.9 mcg/g dry weight in NASH patients (P<0.05). Higher liver copper concentrations were seen in patients with severe steatosis com...Continue Reading
References
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M L BassettL W Powell
Sep 1, 1994·Human Molecular Genetics·K PetrukhinT C Gilliam
Feb 1, 1996·Seminars in Liver Disease·R S Britton
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z M YounossiA J McCullough
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E M Brunt
Jan 22, 2000·Annals of Internal Medicine·S BellentaniC Tiribelli
Mar 13, 2001·Molecular Genetics and Metabolism·P ButlerP K Mistry
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gianfranco PaganoMario Rizzetto
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BugianesiMario Rizzetto
Jul 28, 2004·Diabetes Care·Jesús MedinaRicardo Moreno-Otero
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
May 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Neil D Theise
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A RobertsUNKNOWN American Association for Study of Liver Diseases (AASLD)
Dec 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raj Vuppalanchi, Naga Chalasani
Mar 25, 2010·World Journal of Gastroenterology : WJG·Sandy Cope-YokoyamaValentina Medici
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth M BruntUNKNOWN NASH Clinical Research Network (CRN)
May 19, 2011·Alimentary Pharmacology & Therapeutics·M HjelkremS A Harrison
Citations
Nov 12, 2013·International Journal of Molecular Sciences·Mario ArcielloClara Balsano
Sep 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ibrahim AltraifMohammed Afzal
Apr 24, 2016·La Radiologia medica·Ottavia VargasAnthony Dohan
Aug 1, 2014·Frontiers in Aging Neuroscience·Nady BraidyPerminder Sachdev
Apr 27, 2016·Abdominal Radiology·Anthony DohanPhilippe Soyer
Jan 9, 2015·Clinical Pediatrics·Suchitra K HouriganAnn O Scheimann
Nov 1, 2017·The Journal of Biological Chemistry·Cheri M Ackerman, Christopher J Chang
Apr 22, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Abigael MuchenditsiSvetlana Lutsenko
Feb 24, 2018·Journal of Neurochemistry·Emily ReedOliver Bandmann
Nov 20, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James Hamilton, Svetlana Lutsenko
Apr 24, 2019·International Journal of Molecular Sciences·Simona MarchiselloAgata Maria Rabuazzo
Sep 8, 2018·Nature Reviews. Disease Primers·Anna CzłonkowskaMichael L Schilsky
Feb 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Grażyna GromadzkaAnna Członkowska
Jul 18, 2020·Nutrients·Takashi Himoto, Tsutomu Masaki
Feb 13, 2014·Annals of the New York Academy of Sciences·Peter Ferenci
Dec 18, 2014·World Journal of Gastroenterology : WJG·Ella WeitzmanZiv Ben Ari
Aug 9, 2021·Biochimica Et Biophysica Acta. General Subjects·Bryce BladesSharon La Fontaine