The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease

Biological Trace Element Research
Felipe Nathanael Coelho VazJuliana Sartori Bonini

Abstract

This study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. Patients' cognitive impairment was evaluated by Clinical Dementia Rating (CDR). The elementary quantification of erythrocytes was performed by inductively coupled plasma mass spectrometry technique. The statistical analyses were carried out by SPSS software 20.0 version, employing Shapiro-Wilk, Wilcoxon, Kruskall-Wallis, and Spearman correlation tests, considering significant results of p < 0.05. The sample was composed of 34% (n = 11) of women and 66% (n = 21) of men in each group. The AD group was characterized by a higher concentration of copper (p < 0.0001) and iron (p < 0.0001); however, there is no significant difference in selenium level. The analyses of the metal levels in different stages of AD were not significant in CDR-1, however in CDR-2 and CDR-3, elevated levels of copper and iron were observed; in CDR-3 patients, the level of selenium was lower (p < 0.008) compared to that of healthy controls. Patients with Alzheimer disease...Continue Reading

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Nov 9, 2017·Frontiers in Molecular Neuroscience·Yong LiHong Jiang
Jan 18, 2018·Biological Trace Element Research·Abolfazl JandMohammad Reza Palizvan
May 24, 2020·International Journal of Molecular Sciences·Hatasu KobayashiShinji Oikawa
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Methods Mentioned

BETA
blood collection

Software Mentioned

GPower®
SPSS
GPower

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