The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease.

JACC. Cardiovascular Imaging
Han-Young JinHyuk-Jae Chang

Abstract

The aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease. Coronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in response to medical therapy. This analysis included 925 patients with 2,568 lesions from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry, in which patients underwent clinically indicated serial coronary computed tomography angiography. Plaque calcification was examined by using CPV and percent CPV (PCPV), calculated as (CPV/plaque volume) × 100 at a per-plaque and per-patient level (summation of all individual plaques). CPV was strongly correlated with plaque volume (r = 0.780; p < 0.001) at baseline and with plaque progression (r = 0.297; p < 0.001); however, this association was reversed after accounting for plaque volume at baseline (r = -0.146; p < 0.001). In contrast, PCPV was an independent p...Continue Reading

References

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Citations

Nov 23, 2020·JACC. Cardiovascular Imaging·Miguel Cainzos-Achirica, Tanushree Agrawal
Apr 23, 2021·Expert Review of Cardiovascular Therapy·Filippo CademartiriErica Maffei
Nov 23, 2020·JACC. Cardiovascular Imaging·Miguel Cainzos-AchiricaKhurram Nasir
May 6, 2021·BMJ : British Medical Journal·Khurram Nasir, Miguel Cainzos-Achirica
Jun 5, 2021·Journal of the American College of Cardiology·Xavier RosselloValentin Fuster
Sep 2, 2021·The American Journal of Cardiology·A Maxim BaxHyuk-Jae Chang
Nov 18, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wenjun FanLixian Sun

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