PMID: 9192296May 1, 1997Paper

The relationship between developing oligodendrocyte units and maturing axons during myelinogenesis in the anterior medullary velum of neonatal rats

Journal of Neurocytology
A M ButtM Berry

Abstract

Myelinogenesis was investigated in whole-mounted anterior medullary vela from rats aged postnatal day (P) 10-12, using double immunofluorescence labelling with Rip and anti-neurofilament 200 (NF200) antibodies, to identify oligodendrocytes and axons, respectively. A number of discrete phases of maturation of oligodendrocyte units were recognised. (1) Promyelinating oligodendrocytes co-expressed Rip and Myelin basic Protein and formed axonal associations, prior to ensheathment. (2) Transitional oligodendrocytes contained both ensheathing and non-ensheating processes. (3) Myelinating oligodendrocytes were established after a period of remodelling (in which non-ensheathing processes were lost), appearing as oligodendrocyte unit morphological phenotypes with a definitive number of incipient myelin sheaths. (4) Maturation of myelinating oligodendrocytes was defined as the establishment of internodal sheath lengths and the redistrubution of myelin basic protein from the cell somata and radial processes into the myelin sheaths only. Myelination was probably related to the maturational state of the axons, since it was initiated when the latter had attained a critical diameter of between approximately 0.2 and 0.4 micron, coincident with...Continue Reading

Citations

Dec 24, 2005·Nature Reviews. Neuroscience·William D RichardsonNigel Pringle
Jul 1, 2009·Journal of Neuroscience Research·Menahem EisenbachElior Peles
Feb 13, 2013·Journal of Neurochemistry·George Harauz, Joan M Boggs
Feb 14, 1998·Neuroreport·P V Belichenko, M R Celio
Feb 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nicoletta KessarisWilliam D Richardson
Dec 4, 2003·NMR in Biomedicine·Yuji SuzukiTsutomu Nakada
Dec 31, 2008·Glia·Michael HaberKeith K Murai
Jan 3, 2006·Nature Neuroscience·Nicoletta KessarisWilliam D Richardson
Apr 2, 2002·Molecular and Cellular Neurosciences·D R GoddardA M Butt
Aug 1, 2009·Biochemistry·George HarauzJoan M Boggs
Jul 3, 2003·Molecular and Cellular Neurosciences·Christopher B McBrideJohn D Steeves
Feb 9, 2005·Experimental Neurology·Arthur M Butt, Jennifer Dinsdale
Aug 23, 2005·Brain Research. Brain Research Reviews·Fernando de Castro, Ana Bribián

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