The relationship between development of ultraviolet erythema and release of prostaglandins in guinea pig skin

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S S AdamsC G Mason

Abstract

Ultraviolet erythema in the guinea pid has been in use for many years as a model for assessing the anti-inflammatory potency of non-steroidal anti-inflammatory agents, the degree of erythema usually being estimated about 2 h after u.v. exposure. Using a suction blister technique for obtaining tissue fluid from erythemic and normal skin of the guinea pig we have shown that prostaglandin output in ultraviolet-irradiated skin increases rapidly during the first 2 h after irradiation, at which time the erythema reaches near-maximal development. Flurbiprofen, a potent non-steroidal anti-inflammatory agent, almost totally prevents the appearance of prostaglandins in the blister fluid and significantly reduces the degree of erythema in the skin during this early period. However, in flurbiprofen-treated animals, although prostaglandin synthesis is also suppressed at 4 to 5 h after exposure and is still partially suppressed at 17 h, a well developed erythema nevertheless appears by 4 h. This indicates the appearance of one or more non-prostaglandin mediators in the later stages of the reaction.

References

Dec 8, 1977·Nature·T J Williams, M J Peck
Nov 1, 1977·Postgraduate Medical Journal·N A PlummerA K Black
Jun 1, 1977·Clinical Science and Molecular Medicine·N A PlummerM W Greaves
Sep 1, 1977·Clinical and Experimental Dermatology·A K BlackR A Eady

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Citations

Apr 1, 1992·Journal of Clinical Pharmacology·S S Adams
Sep 1, 1995·The Journal of Pharmacy and Pharmacology·K YokotaM Oda

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