PMID: 842267Jan 1, 1977Paper

The relationship between disposition and duration of action of congeneric series of steroidal neuromuscular blocking agents

Acta Anaesthesiologica Scandinavica
S AgostonA H Scaf

Abstract

The renal and hepatic elimination and biotransformation, as well as the relation between disposition and duration of action of pancuronium and two of its analogues, dacuronium and ORG.6368, have been investigated in the cat. In pharmacokinetic studies, appreciable amounts of the latter two compounds were found in the urine, bile and liver 8 h after their intravenous administration. Various proportions of the injected dose of the respective drugs were metabolized. In another series of experiments it was shown that the early hepatic uptake (during the first 3 min after the injection) of ORG.6368 was significantly greater than that of dacuronium and pancuronium. The intensity and duration of action of the neuromuscular blocking effect of the three compounds were studied after intravenous and "close" intraarterial injection. On the basis of these pharmacokinetic and neuromuscular studies, it was concluded that the short duration of action of ORG.6368 is due primarily to its early hepatic uptake. The possibility cannot be excluded, however, that differences in the kinetics of the drug action of ORG.6368 and the other two compounds also contributed significantly to the differences seen in the duration of action of these compounds.

References

Jan 1, 1975·International Anesthesiology Clinics·F F Foldes
Mar 1, 1974·The Journal of Pharmacy and Pharmacology·D A Kharkevich
May 1, 1970·European Journal of Pharmacology·D K Meijer, J G Weitering
Jul 1, 1970·Anaesthesia·S A Feldman, M F Tyrrell
Feb 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·U W KerstenS Agoston
Oct 22, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·P G Waser
Jan 1, 1973·Acta Anaesthesiologica Scandinavica·S AgostonD K Meijer
Jan 1, 1973·Acta Anaesthesiologica Scandinavica·S AgostonD K Meijer
Dec 1, 1973·The Biochemical Journal·R D HughesR T Williams
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·A Ryrfeldt, E Hansson
Jul 1, 1958·Postgraduate Medical Journal·F F Foldes
Dec 1, 1951·The American Journal of Medicine·G READERJ McLEAN

Citations

Feb 19, 1982·Pharmaceutisch Weekblad. Scientific Edition·L H BooijJ E Crul
Jan 1, 1978·Acta Anaesthesiologica Scandinavica·P DuvaldestinJ M Desmonts
Oct 6, 1992·Biochemical Pharmacology·W E MolD K Meijer
Oct 23, 2013·PloS One·Zhen-Meng WangWei-Feng Yu
Jul 1, 1977·Canadian Anaesthetists' Society Journal·E Yang, C Lee
Jan 1, 1979·Archives of Virology·W RohdeC Scholtissek
Jan 1, 1979·Archives of Virology·P D Minor, N J Dimmock

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