The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population.

Neuropsychiatric Disease and Treatment
Robert H PaulEvian Gordon

Abstract

Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain. In the present study we evaluated this relationship in healthy non-clinical participants using diffusion tensor imaging (DTI) and self-reported history of ELS. Regression analyses revealed significant reductions in fractional anisotropy (FA) within the genu of the corpus callosum among those exposed to the greatest number of early life stressors, suggesting reduced microstructural integrity associated with increased ELS. These effects were most pronounced in the genu of the corpus callosum compared to the body and splenium, and were evident for females rather than males despite no differences in total ELS exposure between the sexes. In addition, a further comparison of those participants who were exposed to no ELS vs. three or more ELS events revealed lower FA in the genu of the corpus callosum among the ELS-exposed group, with trends of FA reduction in the body and the whole corpus callosum. By contrast, there were no relationships between ELS and volumetric analysis of the CC...Continue Reading

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Citations

May 25, 2012·Journal of the International Neuropsychological Society : JINS·Uraina S ClarkKaren T Tashima
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Apr 27, 2021·Frontiers in Neuroscience·Rafiad Islam, Arie Kaffman

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Software Mentioned

MATLAB
Statistical Parametric Mapping ( SPM2 )
Deformation Toolbox , SPM2

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