The relationship between executive dysfunction and post-stroke mortality: a population-based cohort study.

BMJ Open
Bernice WibergLars Lind

Abstract

To study the associations of pre-stroke cognitive performance with mortality after first-ever stroke or transient ischaemic attack (TIA). A prospective cohort study. In participants having first-ever stroke or TIA during up to 14 years of post-test follow-up (n=155), we investigated the associations of pre-stroke variables and cognitive test results with post-stroke survival. The study is based on those participants of the Uppsala Longitudinal Study of Adult Men who performed cognitive function tests at approximately age 70 (n=919). Mortality after first-ever stroke or TIA related to pre-stroke executive performance. Eighty-four (54%) of the first-ever stroke/TIA patients died under a median follow-up of 2.5 years after the event. In Cox proportional hazard analyses adjusting for age, education, social group and traditional stroke risk factors, poor performance in Trail Making Test (TMT)-A was related to mortality (HR 1.88 per SD, 95% CI 1.31 to 2.71, p=0.001). The risk of mortality was approximately threefold higher in the highest tertile compared with the lowest tertile (HR TMT-A= 2.90 per SD, 95% CI 1.24 to 6.77, p=0.014). A similar pattern was seen for TMT-B, but Mini-Mental State Examination results were not related to ris...Continue Reading

Citations

Oct 1, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Tatu KauranenErja Poutiainen
Nov 2, 2013·NeuroImage. Clinical·Thomas M H HopeCathy J Price
Sep 1, 2015·Assessment·Jordi Llinàs-ReglàJosep Garre-Olmo
Mar 7, 2017·Journal of Neurologic Physical Therapy : JNPT·Mayis Al-DughmiCatherine F Siengsukon
Feb 13, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Lauren M MaiSarah T Pendlebury
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Apr 25, 2019·The Clinical Neuropsychologist·Jacobus Donders
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