The Relationship between Exosomes and Cancer: Implications for Diagnostics and Therapeutics

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Wendy W WestonH Thomas Temple

Abstract

Exosomes are very small extracellular vesicles secreted by cells to local and distant tissues. These mini signal transporters elicit acute and chronic effects on recipient cells. Studies regarding exosomes and their relationship to disease, as well as healthy functions, are eliciting extraordinary excitement as data pours in from groups around the world. Reporting of exosome biogenesis, selective loading of cargo, directed release, and resulting changes in adjacent and distal cells are providing information that is changing the way we view cancer progression and treatment. As a result, the properties of exosomes are being exploited for diagnostic, prognostic, and therapeutic applications. First, by referring to the signaling molecules carried by exosomes, they are being tested as indicators of the presence of transformed cells in early stages of cancer. Secondly, the cargo of exosomes secreted from tumors have been linked to prognostic factors and metastatic properties. Thirdly, exosome-based therapies are being developed which utilize the inherent properties of these mini-transporters to affect and interfere with cancer. Exosome creation, loading, and release plays an important role in cancer formation, progression and organot...Continue Reading

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Citations

Jul 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi LiWei Zhang
Aug 6, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Davod JafariAli Samadikuchaksaraei
Sep 19, 2020·Expert Opinion on Biological Therapy·Manica NegahdaripourNavid Nezafat
Aug 28, 2020·Frontiers in Neuroscience·Aurélie LedreuxAnn-Charlotte Granholm
Sep 19, 2020·International Journal of Molecular Sciences·Claudia CavallariMaria Felice Brizzi
Dec 31, 2020·Clinical and Translational Medicine·Shiyu LiKongming Wu
Jan 26, 2021·OncoTargets and Therapy·Miao DaShuwen Han
Mar 17, 2021·Journal of Experimental & Clinical Cancer Research : CR·Haoze LiQing Ji

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Methods Mentioned

BETA
electron microscopy
standard flow
biopsy

Software Mentioned

Nanostring

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