PMID: 16538107Mar 16, 2006Paper

The relationship between gastro-oesophageal reflux symptoms and achalasia

European Journal of Gastroenterology & Hepatology
Simon H C AndersonAngela Anggiansah

Abstract

Patients with achalasia can experience heartburn, which may be misinterpreted as gastro-oesophageal reflux disease (GORD), leading to a delay in diagnosis and subsequent treatment. We investigated the relationship between gastro-oesophageal reflux (GOR) and reflux symptoms in a large cohort of patients with achalasia. The symptoms of all patients with a manometric diagnosis of achalasia made over the past 15 years were studied. The types of treatment, onset and pattern of heartburn, lower oesophageal sphincter pressure (LOSP) and 24-h oesophageal pH studies were compared. A total of 110 out of 225 untreated (48.9%) and 57 out of 99 treated (57.6%) patients experienced heartburn. An oesophageal pH study was performed on 80 patients and GOR was found in only six out of 57 untreated (10.5%) and 10 out of 23 treated (43.5%) patients. A low LOSP (<10 mmHg) was associated with an increased risk of GOR [odds ratio (OR) 14.2; 95% confidence interval (CI) 1.6-128.7; P<0.02). Treated patients were also more likely to develop GOR (OR 7.9; 95% CI 2.0-32.1; P<0.005). Neither the LOSP nor previous treatment was, however, a predictor of heartburn. The timing of the onset of dysphagia and heartburn was categorized in 111 patients. There was no...Continue Reading

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Citations

Dec 29, 2015·The Kaohsiung Journal of Medical Sciences·Hsin-Ming WangChi-Sin Changchien
Oct 15, 2013·Annals of the New York Academy of Sciences·Valter Nilton FelixRoy Wong
Aug 16, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D JasperJ Keller
Jul 12, 2018·Digestive Diseases and Sciences·Laura BognárÖrs Péter Horváth
Nov 14, 2019·Surgical Endoscopy·P NauUNKNOWN SAGES Foregut Task Force White Paper
Oct 14, 2017·United European Gastroenterology Journal·Aurelio MauroRoberto Penagini
Nov 8, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery
Aug 15, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Mohan RamchandaniD Nageshwar Reddy

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