The Relationship Between Gastroesophageal Reflux and Chronic Unexplained Cough in Children

Clinical Pediatrics
Ivan PavićIva Hojsak

Abstract

The aim of this study was to assess the association between chronic cough and acid or weakly acid gastroesophageal reflux (GER) determined by 24-hour multichannel intraluminal impedance-pH monitoring and to assess whether the association is age dependent. Overall 150 children (mean age 7.5 years; range 0.3-18.0 years; male/female 90/60) were enrolled. Median of 87.5% (0% to 100%) of all cough episodes were associated with reflux; 9% (0% to 100%) with acidic and 60% (0% to 100%) with weakly acidic episodes. In 52 children (34.7%), all cough episodes were associated with GER (100% association). Children younger than 2 years had significantly higher number of cough episodes associated with total (P = .03) and weakly acidic GER (P = .01). Binary logistic regression confirmed that only increase in age decreases the risk for complete (100%) association between cough episode and GER. Cough is significantly associated with weakly acidic GER and children of younger age are at higher risk.

References

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Citations

Oct 22, 2016·Journal of Pediatric Gastroenterology and Nutrition·Mark SafeUsha Krishnan
Oct 25, 2016·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·I PavićI Hojsak
May 28, 2019·Minerva pediatrica·Annarita BongiovanniSalvatore Leonardi
Oct 14, 2016·Pediatric Pulmonology·Letizia ZenzeriAnnamaria Staiano
May 29, 2021·Pediatric Gastroenterology, Hepatology & Nutrition·Ivan PavićIva Hojsak

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

SPSS
MMS

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