The Relationship between Gene Network Structure and Expression Variation among Individuals and Species

PLoS Genetics
Karen E SearsZoi Rapti

Abstract

Variation among individuals is a prerequisite of evolution by natural selection. As such, identifying the origins of variation is a fundamental goal of biology. We investigated the link between gene interactions and variation in gene expression among individuals and species using the mammalian limb as a model system. We first built interaction networks for key genes regulating early (outgrowth; E9.5-11) and late (expansion and elongation; E11-13) limb development in mouse. This resulted in an Early (ESN) and Late (LSN) Stage Network. Computational perturbations of these networks suggest that the ESN is more robust. We then quantified levels of the same key genes among mouse individuals and found that they vary less at earlier limb stages and that variation in gene expression is heritable. Finally, we quantified variation in gene expression levels among four mammals with divergent limbs (bat, opossum, mouse and pig) and found that levels vary less among species at earlier limb stages. We also found that variation in gene expression levels among individuals and species are correlated for earlier and later limb development. In conclusion, results are consistent with the robustness of the ESN buffering among-individual variation in...Continue Reading

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Citations

Feb 7, 2017·Nature Reviews. Genetics·Florence PetitNadav Ahituv
Jan 29, 2017·Reproductive Toxicology·Daniel SorensenKaren E Sears
Feb 10, 2017·Proceedings. Biological Sciences·Daniel J UrbanKaren E Sears
Mar 25, 2017·BMC Evolutionary Biology·Jennifer A MaierKaren E Sears
Dec 19, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Simone EckerDirk S Paul
Mar 16, 2019·Physiological Genomics·Tristan V de JongVictor Guryev
Nov 3, 2017·Genesis : the Journal of Genetics and Development·Karen SearsDaniel J Urban
Mar 9, 2021·Current Opinion in Genetics & Development·Aidan O HowenstineKaren E Sears
Nov 24, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bau-Lin Huang, Susan Mackem

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Datasets Mentioned

BETA
GSE71390

Methods Mentioned

BETA
PCR
RNASeq

Software Mentioned

MATLAB

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