The relationship between hemodialysis modality and insulin resistance in non-diabetic hemodialysis patients.

Blood Purification
Sung Jin MoonHyeong-Cheon Park

Abstract

Although various modalities of hemodialysis (HD) are presumed to have different effects on insulin resistance (IR), the relationship between hemodiafiltration (HDF) and IR has not been fully evaluated. In a cross-sectional study, 82 non-diabetic HD patients were enrolled. The patients were divided into two groups according to the median homeostasis model assessment index (HOMA-IR) value of 1.685. Clinical and biochemical data were compared, and multivariate logistic regression analysis was performed to identify the independent factors associated with higher HOMA-IR. The higher HOMA-IR group had increased body mass index (BMI), decreased HDL cholesterol, and lower beta-2 microglobulin reduction rate (β2-MG RR) compared to the lower HOMA-IR group. HOMA-IR was significantly correlated with β2-MG RR. In addition, HDF patients had lower HOMA-IR levels compared with low flux hemodialysis patients. On multivariate logistic regression analysis, BMI and HDF treatment were independent factors associated with higher and lower HOMA-IR, respectively. This study suggests that HDF treatment may reduce IR in non-diabetic HD patients.

Citations

Jun 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Marie-Noel RahhalFaramarz Ismail-Beigi
Jul 17, 2019·BioMed Research International·Tuyen Van DuongShwu-Huey Yang

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