The relationship between hippocampal volume and static postural sway: results from the GAIT study

Age
Olivier BeauchetGilles Allali

Abstract

The role of the hippocampus in postural control, in particular in maintaining upright stance, has not been fully examined in normal aging. This study aims to examine the association of postural sway with hippocampal volume while maintaining upright stance in healthy older individuals. Seventy healthy individuals (mean age 69.7 ± 3.4 years; 41.4 % women) were recruited in this study based on cross-sectional design. Hippocampal volume (quantified from a three-dimensional T1-weighted MRI using semi-automated software), three center of pressure (COP) motion parameters (sway area, path length of anterior-posterior (AP) and medial-lateral (ML) displacement) while maintaining upright stance (eyes open and closed), and the relative difference between open and closed eye conditions were used as outcome measures. Age, sex, body mass index, lower limb proprioception, distance vision, 15-item geriatric depression scale score, total cranial volume, and white matter abnormalities were used as covariates. The sway area decreased from open to closed eye condition but this variation was non-significant (P = 0.244), whereas path length of AP and ML displacement increased significantly (P < 0.003). Increase in sway area from open to closed eyes w...Continue Reading

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Citations

Mar 10, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Patrick J SpartoCaterina Rosano
Dec 6, 2017·Acta Oto-laryngologica·Shinichi GotoAtsushi Matsubara
May 15, 2020·Neuroscience and Biobehavioral Reviews·Bauke W DijkstraAlice Nieuwboer
Apr 4, 2021·NeuroImage. Clinical·Jillian Vinall MillerMelanie Noel

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