The relationship between homotropic and heterotropic cooperativity for angiotensin receptors in smooth muscle

General Pharmacology
M N ScanlonG J Moore

Abstract

1. Angiotensin-induced contraction of smooth muscle is accompanied by both homotropic (receptor-receptor) and heterotropic (receptor-G protein) cooperativity. 2. Binding constants for angiotensins II and III at uterine smooth muscle receptors have been compared in bioassays and binding assays, using the competitive antagonist Sarmesin to verify the binding assay/bioassay interrelationship. 3. Agonist affinities determined from binding studies in the presence of GTP/S were found to be similar to the affinities observed in responding rat uterine tissues under conditions which eliminate positive homotropic cooperativity, suggesting that heterotropic cooperativity and homotropic cooperativity are interdependent events for smooth muscle contraction. 4. The data are consistent with an allosteric or autosteric mechanism of receptor function involving cooperativity between two agonist binding sites on the receptor. 5. The model has been used to calculate homotropic efficacies for angiotensins II and III from bioassay data and binding data, respectively.

References

May 21, 1976·Biochimica Et Biophysica Acta·S Jacobs, P Cuatrecasas
Jan 1, 1975·Advances in Protein Chemistry·G Weber
Sep 10, 1985·European Journal of Pharmacology·Y G Kwok, G J Moore
May 12, 1972·Biochemical and Biophysical Research Communications·G J Moore, N L Benoiton
Dec 16, 1983·Biochemical and Biophysical Research Communications·M B Anand-Srivastava

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Citations

Jul 1, 1995·Journal of Psychosomatic Research·K M PaarlbergH P Van Geijn
Apr 22, 2014·Neuroscience and Biobehavioral Reviews·R Graignic-PhilippeS Tordjman
Oct 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K L HallH L Hosick
Aug 30, 1991·Biochemical and Biophysical Research Communications·R K SharmaG J Moore
Jul 1, 1991·International Journal of Peptide and Protein Research·G J MooreK J Franklin
Jun 16, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G P VinsonO Djahanbakhch
Jan 1, 1991·International Journal of Peptide and Protein Research·J HondrelisG J Moore

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