The Relationship Between Ictal Multi-Unit Activity and the Electrocorticogram

International Journal of Neural Systems
Tahra L EissaW van Drongelen

Abstract

During neocortical seizures in patients with epilepsy, microelectrode array recordings from the ictal core show a strong correlation between the fast, cellular spiking activities and the low-frequency component of the potential field, reflected in the electrocorticogram (ECoG). Here, we model the relationship between the cellular spike activity and this low-frequency component as the input and output signals of a linear time invariant system. Our approach is based on the observation that this relationship can be characterized by a so-called sinc function, the unit impulse response of an ideal (brick-wall) filter. Accordingly, using a brick-wall filter, we are able to convert ictal cellular spike inputs into an output that significantly correlates with the observed seizure activity in the ECoG ( r = 0 . 4 0 - 0 . 5 6 , p < 0 . 0 1 ) , while ECoG recordings of subsequent seizures within patients also show significant, but lower, correlations ( r = 0 . 1 0 - 0 . 3 0 , p < 0 . 0 1 ) . Furthermore, we can produce seizure-like output signals using synthetic spike trains with ictal properties. We propose a possible physiological mechanism to explain the observed properties associated with an ideal filter, and discuss the potential...Continue Reading

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Citations

Aug 29, 2019·Journal of Neurophysiology·Andrew K TrybaWim van Drongelen
Feb 6, 2020·Journal of Neurophysiology·Christoforos A PapasavvasYujiang Wang
Mar 23, 2019·Neurobiology of Disease·Catherine A SchevonAndrew J Trevelyan

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