The relationship between image degradation and myopia in the mammalian eye

Clinical & Experimental Optometry : Journal of the Australian Optometrical Association
Hannah E BowreySally A McFadden

Abstract

In all species studied, myopia develops if the eye is deprived of detailed vision during development (form deprivation myopia). However, different degrees of spatial image deprivation produce different effects and have not been described in the mammalian eye. Therefore, the effect of image degradation on guinea pig emmetropisation was investigated. Eighty-one guinea pigs wore a treatment on one eye from 6 to 13 days of age. There were four treatments: a translucent diffuser (no lines or edges were visible through the diffuser); one of five Bangerter foils (BF: 0.8, 0.6, 0.4, 0.2, light perception only), which differed in their cut-off spatial frequencies; a 'ring mount' control with no filter; or one of two neutral density filters that reduced luminance only (ND, optical density grades 0.1 and 0.6). Refractive error and ocular elongation were measured after seven days of treatment. The extent of induced myopia and ocular growth were related to the amount of image degradation (mean difference between the treated and untreated eyes changed in a graded manner -7.0 D to -0.2 D and from 85 µm to seven µm respectively, for spatial frequency cut-offs between zero and 24 cycles per degree). Corresponding reductions in luminance from ND...Continue Reading

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Citations

Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones
Oct 13, 2019·Cellular and Molecular Neurobiology·Pei ChenJing Zhuang
Aug 22, 2020·Investigative Ophthalmology & Visual Science·Sarah Elizabeth SinghAustin John Roorda
Sep 29, 2020·Investigative Ophthalmology & Visual Science·Daniel Ian FlitcroftChristine Frances Wildsoet
Jul 25, 2017·Biomedical Optics Express·Pablo Pérez-MerinoSusana Marcos
Apr 11, 2019·The British and Irish Orthoptic Journal·Mun Wei Kan, Anne Bjerre
Jan 28, 2021·Investigative Ophthalmology & Visual Science·Erica G LandisMachelle T Pardue
Jun 5, 2021·Communications Biology·Wim H QuintAdriana I Iglesias
Oct 6, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Brian An PengMonica Jong

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