The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Acta Ophthalmologica
Erika YamadaToru Nakazawa

Abstract

Sleep apnoea syndrome (SAS) is often associated with glaucoma, and intermittent hypoxia, present in SAS, can contribute to glaucoma pathogenesis. However, the relationships between SAS, high systemic oxidative stress and the speed of glaucoma progression are unclear. Thus, we investigated these relationships in glaucoma patients with and without SAS. Peripheral blood samples were collected from 166 eyes of 166 Japanese patients: 42 controls, 109 open-angle glaucoma (OAG) patients without SAS and 15 OAG patients with SAS. Prognostic factors for visual field defect progression were determined with logistic regression. Diacron reactive oxygen metabolites (dROM) and biological antioxidant potential (BAP) were measured with a free radical analyser. Clinical parameters were also recorded. Intergroup comparisons used the Mann-Whitney U test. Multiple regression analysis showed that SAS was a statistically significant contributing factor to fast visual field defect progression, defined as mean deviation (MD) slope ≤-2.0 dB/Y (SAS: odds ratio (OR) = 14.48; p = 0.002). The non-SAS and SAS groups had similar age, sex, intraocular pressure (IOP), axial length and antiglaucoma drug use. The SAS group had a significantly higher dROM level (p...Continue Reading

References

May 21, 1998·Ophthalmology·D S MojonC W Hess
May 18, 1999·Ophthalmology·D S MojonJ Mathis
Dec 11, 1999·The Laryngoscope·K K LiC Guilleminault
Mar 18, 2000·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·D S MojonJ Mathis
May 11, 2000·The New England Journal of Medicine·P E PeppardJ Skatrud
Dec 15, 2000·Archives of Ophthalmology·V A PurvinR D Yee
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·C BerryA F Dominiczak
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Nanduri R Prabhakar
Jun 18, 2002·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Daniel S MojonJohannes Mathis
May 13, 2005·Chest·Motoo YamauchiHiroshi Kimura
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
May 26, 2006·British Journal of Clinical Pharmacology·Pietro MinuzLuciano Cominacini
Aug 7, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sarper KarakucukKoray Gumus
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Stefan KiekensJohan Verbraecken
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Vincent PialouxMarc J Poulin
Oct 31, 2009·Journal of the American College of Cardiology·Ken MonahanSusan Redline
Jul 24, 2010·The European Respiratory Journal·B Jurado-GámezJ Lopez-Miranda
Sep 21, 2010·Journal of Glaucoma·Pei-Wen LinMeng-Chih Lin
Oct 17, 2013·Investigative Ophthalmology & Visual Science·Yukihiro ShigaToru Nakazawa
Apr 19, 2015·Respiratory Research·Donato LacedoniaMaria P Foschino Barbaro
Jul 4, 2015·The British Journal of Ophthalmology·Mohammad NaderanMohammad Amin Kamaleddin
Oct 31, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Noriko HimoriToru Nakazawa
Feb 18, 2016·Asia-Pacific Journal of Ophthalmology·Toru Nakazawa
May 27, 2016·Investigative Ophthalmology & Visual Science·Yasuhiro ShinmeiSusumu Ishida
Nov 9, 2016·Frontiers in Immunology·Gillipsie MinhasNooruddin Khan

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Citations

Dec 16, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Noriko HimoriToru Nakazawa
Nov 27, 2019·International Journal of Environmental Research and Public Health·Siu-Fung ChauChia-Yi Lee
Jul 29, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Noriko Himori, Toru Nakazawa
Feb 5, 2021·Journal of Clinical Biochemistry and Nutrition·Kaoru ManabeMasaki Tanito
Jul 21, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Aldara García-SánchezFrancisco García-Rio

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